USP5
USP5，全稱為泛素特異性蛋白酶5，常見別名包括USP5A、USP5B等。該蛋白在細胞中發(fā)揮去泛素化酶的作用，通過移除泛素分子來調(diào)節(jié)泛素化修飾的蛋白質(zhì)功能。USP5蛋白與多種細胞過程密切相關(guān)，包括細胞增殖、凋亡、DNA修復(fù)和信號轉(zhuǎn)導(dǎo)等。USP5蛋白在多種疾病中發(fā)揮作用，如癌癥、神經(jīng)退行性疾病和自身免疫性疾病等。近年來，USP5蛋白成為藥物研發(fā)的新靶點。研究表明，USP5蛋白的表達水平與某些癌癥的發(fā)生發(fā)展密切相關(guān)，如乳腺癌、結(jié)直腸癌和肝癌等。因此，針對USP5蛋白的抑制劑或激活劑可能成為治療這些癌癥的新策略。此外，USP5蛋白在神經(jīng)退行性疾病中的作用也引起了廣泛關(guān)注。研究表明，USP5蛋白的表達水平與阿爾茨海默病和帕金森病等神經(jīng)退行性疾病的病理生理過程密切相關(guān)。因此，USP5蛋白可能成為治療這些神經(jīng)退行性疾病的潛在靶點。
熱銷產(chǎn)品
USP5 Recombinant Monoclonal Antibody (CSB-RA288313A0HU)
驗證數(shù)據(jù)
Flow cytometric analysis of ubiquitin specific peptidase 5 expression in HepG2 cells using ubiquitin specific peptidase 5 antibody. Green, isotype control; red, ubiquitin specific peptidase 5.
Immunocytochemical staining of HepG2 cells with Ubiquitin specific peptidase 5 antibody. Nuclei were stained blue with DAPI; Ubiquitin specific peptidase 5 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
Western blotting analysis using ubiquitin specific peptidase 5 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with ubiquitin specific peptidase 5 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
USP5 Antibody (CSB-PA025742LA01HU)
驗證數(shù)據(jù)
Western blot
All lanes: USP5 antibody at 10µg/ml
Lane 1: Mouse brain tissue
Lane 2: A549 whole cell lysate
Lane 3: MCF-7 whole cell lysate
Lane 4: A375 whole cell lysate
Lane 5: U251 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 96, 94 kDa
Observed band size: 96 kDa
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA025742LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA025742LA01HU at dilution of 1:100
USP5 Antibodies
USP5 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA025742GA01HU | USP5 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA032081 | USP5 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA075147 | USP5 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA025742LA01HU | USP5 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA025742LB01HU | USP5 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA025742LC01HU | USP5 Antibody, FITC conjugated | Human | |
| CSB-PA025742LD01HU | USP5 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA288313A0HU | USP5 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, FC, ICC |
USP5 Proteins
USP5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025742HU CSB-EP025742HU CSB-BP025742HU CSB-MP025742HU CSB-EP025742HU-B |
Recombinant Human Ubiquitin carboxyl-terminal hydrolase 5 (USP5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
