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抗Payload抗體

抗體藥物偶聯物(ADCs)是一種新型的抗癌藥物,結合了單克隆抗體和小分子毒素,具有高度靶向性和高毒素性。由于ADC 給藥后會發生payload 的解結合,導致未結合的payload 的增加和ADC 成分(即DAR 分布)的變化。因此,對偶聯的抗體和偶聯在抗體上的payload 的體內定量分析有助于評估ADC 藥效,并有助于評估payload 在靶點的暴露情況,且確定DAR 分布和平均DAR 值的變化對于提供ADC 的穩定性等整體評估至關重要。

華美CUSABIO推出適用于臨床前及臨床階段抗體藥有效研究工具——抗Payload抗體。可用于ADC藥物的血漿/血清動力學分析、藥物結合親和力的測定、DAR值分析以及ADC藥物的療效評估。

ADC 各成分與其對應分析方法

ADC 的生物分析需要一種綜合的生物分析方法,包括配體結合測定和高效液相色譜串聯質譜聯用技術(LC-MS/MS),分別用于大分子和小分子生物分析。抗payload 抗體在ADC 的免疫原性分析中至關重要,用于免疫原性分析的橋接檢測方法(Bridging LBA)。

Analyte Type Description Typical analytical platforms
Total antibody Total antibody (conjugated or unconjugated) LBA, hybrid LC-MS/MS
Total ADC Total conjugated antibody (DAR > 1)OR LBA
Total payload conjugated to antibody (DAR > 1) LBA hybrid LC-MS/MS
Unconjugated payload Payload not conjugated to antibody LC-MS/MS

(Faria et al., 2022. Doi:10.1007/978-3-030-97193-9_3)

ADC有效荷載-Anti DXD

DXD-新一代ADC最具前景的有效荷載

圖1. DXD-新一代ADC最具前景的有效荷載 [1]

應用場景

藥代動力學(PK)分析

偶聯DAR值定性分析

免疫原性分析

臨床前及臨床階段抗藥物抗體開發

產品優勢

高純度

純度經SDS-PAGE驗證大于90%

高特異性

能夠特異性識別小分子毒素

高靈敏度,高親和性

經ADC藥物結合驗證表現出顯著活性

易于檢測,節省成本

經過HRP標記的抗DXD抗體方便檢測,且無需再與二抗結合

專業技術團隊

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產品列表

產品名稱 產品貨號 應用類型 純化方法
DXD Recombinant Monoclonal Antibody CSB-RA996977I1m ELISA Affinity-chromatography
DXD Recombinant Monoclonal Antibody CSB-RA996977I1h ELISA Affinity-chromatography
DXD Monoclonal Antibody CSB-MA996977I1m ELISA >95%, Protein G purified
DXD Monoclonal Antibody CSB-MA996977I2m ELISA >95%, Protein G purified
DXD Monoclonal Antibody, HRP conjugated CSB-MA996977I1m-B ELISA >95%, Protein G purified
DXD Monoclonal Antibody, HRP conjugated CSB-MA996977I2m-B ELISA >95%, Protein G purified
DM1 Monoclonal Antibody CSB-MA989454I0m ELISA >95%, Protein G purified
DM1&DM4 Monoclonal Antibody CSB-MA989811I0m ELISA >95%, Protein G purified
DM1&DM4 Monoclonal Antibody CSB-MA989811I1m ELISA >95%, Protein G purified
DM1&DM4 Monoclonal Antibody CSB-MA989811I2m ELISA >95%, Protein G purified
DM1&DM4 Monoclonal Antibody CSB-MA989811I3m ELISA >95%, Protein G purified
Eribulin Recombinant Monoclonal Antibody CSB-RA943989I1m ELISA Affinity-chromatography
Eribulin Monoclonal Antibody CSB-MA943989I1m ELISA >95%, Protein G purified
MMAE&MMAF Recombinant Monoclonal Antibody CSB-RA903890I1m ELISA Affinity-chromatography
MMAE&MMAF Monoclonal Antibody CSB-MA903890I1m ELISA >95%, Protein G purified
SN38 Recombinant Monoclonal Antibody CSB-RA187707I1m ELISA Affinity-chromatography
SN38 Monoclonal Antibody CSB-MA187707I1m ELISA >95%, Protein G purified

驗證數據

High purity verified by SEC-HPLC and SDS-PAGE
(Code: CSB-MA996977I2m)
SDS-PAGE驗證

The Mouse Anti-DXD Antibody (Code: CSB-MA996977I2m) has a purity of more than 90% as determined by SEC-HPLC and SDS-PAGE.

High purity verified by SEC-HPLC and SDS-PAGE
(Code: CSB-MA943989I1m)
SDS-PAGE驗證

The Mouse Anti-DXD Antibody (Code: CSB-MA943989I1m) has a purity of more than 98% as determined by SEC-HPLC and SDS-PAGE.

The Binding Activity of Disitamab vedotin (Synonyms: RC48) with Anti-MMAE antibody
(Code: CSB-MA903890I1m)
活性驗證

Activity: Measured by its binding ability in a functional ELISA. Immobilized Disitamab vedotin (Synonyms: RC48) at 2 μg/mL can bind Anti-MMAE antibody, the EC50 is 11.65 to 15.97 ng/mL.

The Binding Activity of T-DXd(DS-8201) with Anti-DXD antibody
(Code: CSB-MA996977I2m)
活性驗證

Activity: Measured by its binding ability in a functional ELISA. Immobilized T-DXd(DS-8201) at 2 μg/mL can bind Anti-DXD antibody, the activity was 4-5 times that of other companies.

定制服務

華美生物已研發多種高純度、高靈敏度,高親和力的抗Payload抗體,可用于ADC藥物的臨床前及臨床階段DAR值和PK分析,可提供定制化的抗Payload抗體,以滿足客戶的個性化需求。

參考文獻:

[1] Kumar, Seema, ed. An Introduction to Bioanalysis of Biopharmaceuticals. Vol. 57. Springer Nature, 2022.



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