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RO60

RO60,全稱為RNA結合蛋白Ro60,也被稱為SS-A或TROVE2,是一種在動物細胞中廣泛存在的RNA結合蛋白。它通常以自由蛋白形式存在,或作為核糖核蛋白復合物的一部分,與Y RNAs等非編碼RNA結合。RO60具有環狀結構,其外表面結合Y RNAs,而內部腔室則可以結合錯折疊的非編碼RNA。這種結合方式有助于清除細胞內的異常RNA分子,維持RNA穩態。RO60蛋白在多種自身免疫性疾病中作為抗體靶點,如干燥綜合征、系統性紅斑狼瘡和新生兒紅斑狼瘡。此外,RO60蛋白還與胃癌的多藥耐藥性相關,研究表明其可能參與腫瘤細胞的耐藥機制。目前,針對RO60蛋白的藥物研發主要集中在免疫調節和抗腫瘤領域,旨在通過抑制RO60蛋白的功能來治療相關疾病。

熱銷產品

Recombinant Human RNA-binding protein RO60 (RO60), partial (CSB-EP025071HU1)

驗證數據

CSB-EP025071HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TROVE2 Antibody (CSB-PA13749A0Rb)

驗證數據

CSB-PA13749A0Rb

Western blot
All lanes: TROVE2 antibody at 2µg/ml
Lane 1: Hela whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 61, 24, 59, 60 kDa
Observed band size: 61 kDa

CSB-PA13749A0Rb

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA13749A0Rb at dilution of 1:20

CSB-PA13749A0Rb

Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA13749A0Rb at dilution of 1:20

CSB-PA13749A0Rb

Western Blot
Positive WB detected in: MCF-7 whole cell lysate, Hela whole cell lysate, PC-3 whole cell lysate, Mouse heart tissue, Mouse spleen tissue, Mouse lung tissue
All lanes: TROVE2 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 61, 24, 59, 60 kDa
Observed band size: 61 kDa

CSB-PA13749A0Rb

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA13749A0Rb at dilution of 1:100

CSB-PA13749A0Rb

Immunofluorescent analysis of A549 cells using CSB-PA13749A0Rb at dilution of 1:100

CSB-PA13749A0Rb

Western Blot
Positive WB detected in: Hela whole cell lysate, Rat kidney tissue
All lanes: TROVE2 antibody at 3.4µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 61, 24, 59, 60 kDa
Observed band size: 61 kDa

CSB-PA13749A0Rb

Immunofluorescent analysis of PC-3 cells using CSB-PA13749A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

CSB-PA13749A0Rb

Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA13749A0Rb at dilution of 1:100

RO60 Antibodies

RO60 for Homo sapiens (Human)

RO60 Proteins

RO60 Proteins for Homo sapiens (Human)