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TROVE2 Antibody, Biotin conjugated

  • 中文名稱:
    TROVE2兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA13749D0Rb
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TROVE2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    TROVE2
  • 別名:
    60 kDa ribonucleoprotein Ro antibody; 60 kDa Ro protein antibody; 60 kDa SS A/Ro ribonucleoprotein antibody; 60 kDa SS-A/Ro ribonucleoprotein antibody; Autoantigen Ro/SSA, 60-KD antibody; bA101E13.2 antibody; Gastric cancer multi drug resistance protein antibody; Ribonucleoprotein autoantigen SS A/Ro antibody; RO 60 antibody; Ro 60 kDa autoantigen antibody; RO60 antibody; RO60_HUMAN antibody; RoRNP antibody; Sjoegren syndrome antigen A2 antibody; Sjoegren syndrome type A antigen antibody; Sjogren syndrome antigen A2 (60kD ribonucleoprotein autoantigen SS A/Ro) antibody; Sjogren syndrome antigen A2 (60kDa ribonucleoprotein autoantigen SS A/Ro) antibody; Sjogren syndrome antigen A2 antibody; SS A antibody; SS-A antibody; SS-A/Ro antibody; SSA 2 antibody; SSA antibody; SSA2 antibody; TROVE 2 antibody; TROVE domain family member 2 antibody; TROVE2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human 60 kDa SS-A/Ro ribonucleoprotein protein (3-535AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation. Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammaotry cytokine secretion. Regulates the expression of Alu retroelements as well as inflammatory genes.; May play roles in cilia formation and/or maintenance.
  • 基因功能參考文獻:
    1. TROVE2 is a novel target of miR-128 in astrocytoma tissues and the expression of TROVE2 is increased with the pathological stages increasing. PMID: 26307612
    2. Significant relationships were found between clinical and laboratory manifestations of autoimmune and rheumatic diseases with different patterns of antibodies to anti-Ro52, anti-Ro60 and anti-La. PMID: 26725021
    3. These findings establish a link among the lupus autoantigen Ro60, Alu retroelements, and type I interferon. PMID: 26382853
    4. Findings indicate a relentless turnover of short-lived clonotypic variants, masquerading as long-lived Ro60 humoral autoimmunity. PMID: 23644453
    5. The Y3 RNA moiety of the Ro60 ribonucleoprotein plays a critical role in the pathogenesis of fetal cardiac injury by altering the subcellular location of Ro60 autoantibodies. PMID: 23698747
    6. these data indicate that ZBP1 may function as an adapter to export the Ro/Y3 RNA complex from nuclei. PMID: 22114317
    7. conclude that RNPs containing hY RNAs and Ro60, La or nucleolin are not required for the function of hY RNAs in chromosomal DNA replication in a human cell-free system, which can be mediated by Y RNAs outside of these RNPs PMID: 21060685
    8. dichotomy of human autoantibody responses against mutually exclusive determinants linked to a single domain of a systemic autoantigen and supports a model in which tolerance is broken by different immunogenic forms of Ro 60 PMID: 20131295
    9. Activation of Toll-like receptors by fetal factor Ro60-associated single-stranded RNA particles is relevant in autoimmune-associated congenital heart block, where the obligate maternal factor is an anti-SSA/Ro autoantibody. PMID: 20089705
    10. In viitro RNA chaperone activity of SSA2 was studied. PMID: 15928345
    11. The structural organization and Zn2+-dependent subdomain interactions involving autoiantigenic epitopes in the RBBC region of SS-A were studied. PMID: 15964842
    12. interactions between Ro-Y5 and L5-5S RNPs establish 5S RNA as a target of quality control PMID: 18056422
    13. results demonstrate that Ro 60 functions as a novel receptor for beta(2)GPI on the surface of apoptotic cells. The formation of Ro 60-beta(2)GPI complexes may protect against anti-Ro 60 autoantibody-mediated tissue injury. PMID: 19248095

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  • 亞細胞定位:
    Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
  • 蛋白家族:
    Ro 60 kDa family
  • 數據庫鏈接:

    HGNC: 11313

    OMIM: 600063

    KEGG: hsa:6738

    STRING: 9606.ENSP00000356411

    UniGene: Hs.288178



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