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POSTN

POSTN,全稱為Periostin,別名OSF2、PDLPOSTN、PN,是一種細胞外基質分泌蛋白,在心肌梗死后的組織發育和再生中發揮重要作用,涉及傷口愈合和心室重構。該蛋白與整合素和BMP1結合,支持細胞粘附、細胞遷移,與多種生理和病理過程相關。POSTN在骨關節炎的軟骨細胞中高度表達,促進細胞外基質的降解和上調炎癥因子,加速疾病進展。此外,POSTN還與腫瘤的遷移、增殖和血管生成能力有關,在多種腫瘤組織中表達上調。在藥物研發方面,針對POSTN的藥物正在開發中,旨在通過抑制POSTN的表達或活性,治療心血管疾病、骨關節炎和腫瘤等疾病。一些研究顯示,抑制POSTN可以減少心臟瓣膜疾病、骨骼和牙齒缺陷的發生。目前,POSTN已成為藥物研發的一個重要靶點,相關藥物正處于臨床研究階段。

熱銷產品

POSTN Recombinant Monoclonal Antibody (CSB-RA119753A0HU)

驗證數據

CSB-RA119753A0HU

IHC image of CSB-RA119753A0HU diluted at 1:50 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.31% DAB.

CSB-RA119753A0HU

Overlay Peak curve showing 293T cells stained with CSB-RA119753A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

Human periostin/osteoblast specific factor 2 (POSTN) ELISA kit (CSB-E16444h)

驗證數據

CSB-E16444h 標準曲線

貨號:CSB-E16444h

規格:96T/48T

靈敏度:1.56 ng/mL

檢測范圍:6.25 ng/mL-400 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

POSTN Antibodies

POSTN for Homo sapiens (Human)

POSTN ELISA Kit

POSTN ELISA Kit for Homo sapiens (Human)