PLEKHA1
PLEKHA1，全稱為Pleckstrin Homology Domain Containing Family A, Member 1，常見別名包括TAPP1和Tandem PH Domain Containing Protein-1。該蛋白主要參與細(xì)胞膜信號傳導(dǎo)和膜運(yùn)輸?shù)冗^程，通過其PH結(jié)構(gòu)域與其他蛋白質(zhì)或膜脂相互作用，可能參與調(diào)控細(xì)胞骨架重組或信號通路。PLEKHA1蛋白在細(xì)胞黏附、極性和增殖中發(fā)揮重要作用，尤其與上皮細(xì)胞的緊密連接相關(guān)。研究表明，PLEKHA1蛋白的表達(dá)水平異常可能與某些癌癥的發(fā)生發(fā)展相關(guān)，例如乳腺癌、結(jié)腸癌等。過表達(dá)PLEKHA1可能破壞細(xì)胞間連接，促進(jìn)腫瘤進(jìn)展；而降低表達(dá)可能導(dǎo)致細(xì)胞極性喪失或信號傳導(dǎo)紊亂。目前，針對PLEKHA1蛋白的藥物研發(fā)尚處于探索階段，但已有研究表明，通過調(diào)節(jié)PLEKHA1蛋白的表達(dá)水平或活性，可能對腫瘤的治療具有一定的作用。
熱銷產(chǎn)品
PLEKHA1 Recombinant Monoclonal Antibody (CSB-RA918477A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Hela whole cell lysate, A549 whole cell lysate, PC-3 whole cell lysate, MCF-7 whole cell lysate
All lanes: PLEKHA1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 46, 39 kDa
Observed band size: 36-55 kDa
PLEKHA1 Antibody (CSB-PA864016DSR1HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA864016DSR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA864016DSR1HU at dilution of 1:100
PLEKHA1 Antibodies
PLEKHA1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA018154GA01HU | PLEKHA1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA864016DSR1HU | PLEKHA1 Antibody | Human | ELISA, IHC |
| CSB-PA864016DSR2HU | PLEKHA1 Antibody | Human | ELISA, WB, IHC |
| CSB-RA918477A0HU | PLEKHA1 Recombinant Monoclonal Antibody | Human | ELISA, WB |
PLEKHA1 Proteins
PLEKHA1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP864016HU CSB-EP864016HU CSB-BP864016HU CSB-MP864016HU CSB-EP864016HU-B |
Recombinant Human Pleckstrin homology domain-containing family A member 1 (PLEKHA1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
