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OSM

OSM,全稱為 Oncostatin M,是一種細胞因子,在調節炎癥和腫瘤等生理和病理功能中發揮重要作用。OSM蛋白主要由活化的巨噬細胞、腫瘤相關成纖維細胞、T細胞、樹突狀細胞和中性粒細胞等多種細胞合成和分泌。OSM蛋白通過與gp130細胞外細胞因子結合同源區結合,隨后招募LIFRβ形成I型受體復合物或OSMRβ形成II型受體復合物,激活多種信號通路,參與多種生理和病理功能,包括炎癥、腫瘤和肌肉萎縮等。OSM蛋白在肺部炎癥和腫瘤中發揮重要作用,例如在肺纖維化、哮喘和慢性阻塞性肺疾病中,OSM蛋白參與細胞外基質蛋白沉積或分解代謝、細胞增殖和細胞存活等過程的調控。此外,OSM蛋白還與肺癌和惡病質等疾病相關。目前,針對OSM蛋白通路藥物的臨床前研究取得了一定進展,例如抗OSM抗體和納米抗體等,顯示出良好的治療效果,但尚無藥物獲批用于臨床疾病的治療。未來,OSM蛋白通路藥物有望成為治療肺部疾病和腫瘤等疾病的新選擇。

熱銷產品

Recombinant Human Oncostatin-M (OSM), partial (Active) (CSB-MP017260HU1)

驗證數據

CSB-MP017260HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP017260HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human OSM at 2μg/mL can bind Anti-OSM recombinant antibody (CSB-RA017260MA1HU),the EC50 is 3.048-3.860 ng/mL.

CSB-MP017260HU1

OSM Recombinant Monoclonal Antibody (CSB-RA017260MA1HU) captured on Protein A Chip can bind Recombinant Human OSM protein with an affinity constant of 0.59 nM as detected by MetaSPR Assay (WeSPRTM 200).

Recombinant Human Oncostatin-M (OSM) (Active) (CSB-MP017260HU-WD)

驗證數據

CSB-MP017260HU-WD

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

OSM Recombinant Monoclonal Antibody (CSB-RA017260MA1HU)

驗證數據

CSB-RA017260MA1HU

The Binding Activity of Human OSM with Anti-OSM Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human OSM (CSB-MP017260HU1) at 2 μg/mL can bind Anti-OSM recombinant antibody, the EC50 is 3.048-3.860 ng/mL.

OSM Antibody (CSB-PA09694A0Rb)

驗證數據

CSB-PA09694A0Rb

IHC image of CSB-PA09694A0Rb diluted at 1:90 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA09694A0Rb

IHC image of CSB-PA09694A0Rb diluted at 1:90 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human Oncostatin-M,OSM ELISA KIT (CSB-E04696h)

驗證數據

CSB-E04696h 標準曲線

貨號:CSB-E04696h

規格:96T/48T

靈敏度:1.56 pg/mL

檢測范圍:6.25 pg/mL-400 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

OSM Antibodies

OSM for Homo sapiens (Human)

OSM for Rattus norvegicus (Rat)

OSM Proteins

OSM Proteins for Homo sapiens (Human)

OSM Proteins for Bos taurus (Bovine)

OSM Proteins for Mus musculus (Mouse)

OSM Proteins for Rattus norvegicus (Rat)

OSM ELISA Kit

OSM ELISA Kit for Homo sapiens (Human)

OSM ELISA Kit for Mus musculus (Mouse)

OSM ELISA Kit for Rattus norvegicus (Rat)



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