NOTCH3
NOTCH3，全稱為Neurogenic locus notch homolog protein 3，是一種重要的細(xì)胞表面受體蛋白，在血管發(fā)育和維持血管壁完整性中發(fā)揮關(guān)鍵作用。該蛋白常見別名為Ehmt2，通過(guò)與其他蛋白結(jié)合激活信號(hào)通路，進(jìn)而影響靶基因表達(dá)。NOTCH3蛋白與JAGGED或DELTA家族蛋白等配體結(jié)合后，能夠調(diào)控細(xì)胞增殖、分化和凋亡等過(guò)程，對(duì)血管的形成和功能維持至關(guān)重要。研究表明，NOTCH3蛋白的異常表達(dá)或活性與多種疾病相關(guān)，包括腦小血管疾病、T細(xì)胞急性淋巴細(xì)胞白血病等。針對(duì)NOTCH3蛋白的藥物研發(fā)已成為研究熱點(diǎn)，目前已有多種靶向藥物處于臨床開發(fā)階段，如抗Notch3激動(dòng)性抗體等，為相關(guān)疾病的治療提供了新的思路。
熱銷產(chǎn)品
NOTCH3 Antibody (CSB-PA892153LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA892153LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA892153LA01HU at dilution of 1:100
Human Neurogenic locus notch homolog protein 3(NOTCH3) ELISA kit (CSB-EL015952HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL015952HU
規(guī)格：96T/48T
靈敏度：31.25 pg/mL
檢測(cè)范圍：125 pg/mL-8000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
NOTCH3 Antibodies
NOTCH3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA015952GA01HU | NOTCH3 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA586591 | NOTCH3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA892153LA01HU | NOTCH3 Antibody | Human | ELISA, IHC |
| CSB-PA892153LB01HU | NOTCH3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA892153LC01HU | NOTCH3 Antibody, FITC conjugated | Human | |
| CSB-PA892153LD01HU | NOTCH3 Antibody, Biotin conjugated | Human | ELISA |
NOTCH3 Proteins
NOTCH3 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP733800MO CSB-EP733800MO CSB-BP733800MO CSB-MP733800MO CSB-EP733800MO-B |
Recombinant Mouse Neurogenic locus notch homolog protein 3 (Notch3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NOTCH3 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP865638RA CSB-EP865638RA CSB-BP865638RA CSB-MP865638RA CSB-EP865638RA-B |
Recombinant Rat Neurogenic locus notch homolog protein 3 (Notch3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NOTCH3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP892153HU CSB-EP892153HU CSB-BP892153HU CSB-MP892153HU CSB-EP892153HU-B |
Recombinant Human Neurogenic locus notch homolog protein 3 (NOTCH3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NOTCH3 ELISA Kit
NOTCH3 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL015952HU | Human Neurogenic locus notch homolog protein 3(NOTCH3) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 31.25 pg/mL |
