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ILDR2

ILDR2蛋白全稱為免疫球蛋白樣結構域受體2,也被稱為IMD2或LISCH樣蛋白,其分子結構中含有典型的免疫球蛋白功能域,主要分布于上皮細胞表面。該蛋白在維持細胞極性及細胞間連接中發揮關鍵作用,尤其與內耳毛細胞、肝臟及乳腺等組織的發育密切相關。ILDR2功能異常可能引發先天性耳聾、膽管閉鎖及部分乳腺癌的發生,例如某些病例中ILDR2基因突變導致聽覺神經信號傳遞受阻,進而引發非綜合征型聽力損傷。
近年來,ILDR2與代謝調控的關聯逐漸被揭示。在糖尿病研究中,ILDR2通過影響胰島素分泌細胞的完整性,可能參與血糖平衡調節。此外,針對ILDR2的藥物開發尚處于早期階段,但其在腫瘤微環境中的特殊表達模式已引起關注,部分抗體藥物偶聯物(ADC)研究將其作為潛在靶點。ILDR2與緊密連接蛋白家族的功能協同性,為治療上皮屏障相關疾病提供了新思路,例如炎癥性腸病的干預策略探索。

熱銷產品

Recombinant Human Immunoglobulin-like domain-containing receptor 2 (ILDR2), partial (CSB-EP751251HU)

驗證數據

CSB-EP751251HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ILDR2 Recombinant Monoclonal Antibody (CSB-RA751251MA1HU)

驗證數據

CSB-RA751251MA1HU

Immunofluorescence staining of Hela cell with CSB-RA751251MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Human IgG(H+L).

CSB-RA751251MA1HU

Immunofluorescence staining of U251 cell with CSB-RA751251MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Human IgG(H+L).

CSB-RA751251MA1HU

Overlay Peak curve showing Jurkat cells stained with CSB-RA751251MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100.Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

ILDR2 Antibodies

ILDR2 for Homo sapiens (Human)

ILDR2 Proteins

ILDR2 Proteins for Homo sapiens (Human)



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