国产午夜福利片1000无码丨人妻国产成人久久av免费高清丨午夜做受视频试看6次丨日韩av不卡一区在线免费观看丨在线观看精品三级欧美

Your Good Partner in Biology Research

IGF1R

IGF1R,全稱胰島素樣生長(zhǎng)因子1受體蛋白,是一種細(xì)胞表面受體,參與生長(zhǎng)調(diào)節(jié)和發(fā)育。它也被稱為IGFIR、IGFR、JTK13、CD221、MGC142170、MGC142172、MGC18216等。IGF1R蛋白的失調(diào)與癌癥和生長(zhǎng)障礙等疾病有關(guān)。靶向IGF1R蛋白可能通過(guò)調(diào)節(jié)細(xì)胞生長(zhǎng)、抑制腫瘤進(jìn)展和管理生長(zhǎng)相關(guān)疾病,為這些疾病提供潛在的治療干預(yù)。
IGF1R蛋白在多種信號(hào)通路中發(fā)揮重要作用,包括PI3K-AKT/PKB、Ras-MAPK、JAK/STAT和JNK通路。這些通路涉及細(xì)胞的生長(zhǎng)、存活、增殖和轉(zhuǎn)化。IGF1R蛋白的高表達(dá)與多種癌癥的發(fā)生發(fā)展有關(guān),如非小細(xì)胞肺癌、乳腺癌、結(jié)直腸癌等。此外,IGF1R蛋白也與一些其他疾病有關(guān),如2型糖尿病、骨質(zhì)疏松等。
目前,針對(duì)IGF1R蛋白的藥物研發(fā)主要集中在抗體類藥物和小分子抑制劑。抗體類藥物可以通過(guò)結(jié)合IGF1R蛋白,阻斷其信號(hào)通路,從而抑制腫瘤細(xì)胞的增殖和轉(zhuǎn)移。小分子抑制劑可以抑制IGF1R蛋白的激酶活性,從而抑制腫瘤細(xì)胞的生長(zhǎng)和增殖。目前,已有多種IGF1R靶向藥物進(jìn)入臨床試驗(yàn)階段,部分藥物已獲得批準(zhǔn)上市,為癌癥患者提供了新的治療選擇。

熱銷產(chǎn)品

Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial (Active) (CSB-MP011087HU1)

驗(yàn)證數(shù)據(jù)

CSB-MP011087HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP011087HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human IGF1R at 2 μg/ml can bind Anti-IGF1R recombinant antibody (CSB-RA011087MA2HU). The EC50 is 1.479-1.702 ng/mL.

CSB-MP011087HU1

The purity of IGF1R was greater than 90% as determined by SEC-HPLC

IGF1R Recombinant Monoclonal Antibody (CSB-RA011087MA2HU)

驗(yàn)證數(shù)據(jù)

CSB-RA011087MA2HU

The Binding Activity of Human IGF1R with Anti-IGF1R Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IGF1R (CSB-MP011087HU1) at 2 μg/mL can bind Anti-IGF1R recombinant antibody. The EC50 is 1.479-1.702 ng/mL.

CSB-RA011087MA2HU

IHC image of CSB-RA011087MA2HU diluted at 1:50 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Anti-Human lgG, Fcy Fragment Specific labeled by HRP and visualized using 0.05% DAB.

CSB-RA011087MA2HU

IHC image of CSB-RA011087MA2HU diluted at 1:50 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Anti-Human lgG, Fcy Fragment Specific labeled by HRP and visualized using 0.05% DAB.

CSB-RA011087MA2HU

Immunofluorescence staining of MCF-7 cell with CSB-RA011087MA2HU at 1:30 ,counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Fluorescein (FITC) AffiniPure Goat Anti-Human IgG, Fcγ fragment specific.

CSB-RA011087MA2HU

Immunofluorescence staining of SH-SY5Y cell with CSB-RA011087MA2HU at 1:30 ,counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Fluorescein (FITC) AffiniPure Goat Anti-Human IgG, Fcγ fragment specific.

CSB-RA011087MA2HU

Overlay Peak curve showing Hela cells stained with CSB-RA011087MA2HU (red line) at 1:100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was Fluorescein (FITC) AffiniPure Goat Anti-Human IgG, Fcγ fragment specific at 1:200 dilution for 35 min at 4℃.Control antibody (green line) was mouse IgG2a (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

Human insulin-like growth factors 1 receptor,IGF-1R ELISA Kit (CSB-E13766h)

驗(yàn)證數(shù)據(jù)

CSB-E13766h 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-E13766h

規(guī)格:96T/48T

靈敏度:0.078 ng/mL

檢測(cè)范圍:0.312 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

IGF1R Antibodies

IGF1R for Homo sapiens (Human)

IGF1R Proteins

IGF1R Proteins for Rattus norvegicus (Rat)

IGF1R Proteins for Homo sapiens (Human)

IGF1R Proteins for Xenopus laevis (African clawed frog)

IGF1R Proteins for Mus musculus (Mouse)

IGF1R Proteins for Sus scrofa (Pig)

IGF1R Proteins for Homo sapiens (Human) parvovirus B19 (isolate AU) (HPV B19)

IGF1R ELISA Kit

IGF1R ELISA Kit for Homo sapiens (Human)

IGF1R ELISA Kit for Rattus norvegicus (Rat)



主站蜘蛛池模板: 久治县| 孟村| 清远市| 钟山县| 林西县| 马山县| 绥江县| 福泉市| 广丰县| 武川县| 元朗区| 崇左市| 个旧市| 怀集县| 宁明县| 商丘市| 武川县| 教育| 衡南县| 洛川县| 荆州市| 汨罗市| 临颍县| 彰化市| 郧西县| 白河县| 溆浦县| 安多县| 虹口区| 台北市| 甘泉县| 革吉县| 陇川县| 米易县| 昌宁县| 遂溪县| 武城县| 新宁县| 长泰县| 平度市| 积石山|