HDAC1
HDAC1，即組蛋白去乙酰化酶1，別名GON 10、HD1、HDAC 1、Histone deacetylase 1、Reduced potassium dependency yeast homolog like 1、RPD3、RPD3L1。它是一種由HDAC1基因編碼的酶，屬于組蛋白去乙酰化酶家族成員之一，主要在細(xì)胞核中發(fā)揮作用。HDAC1的作用機(jī)制主要是通過去除組蛋白上的乙酰基團(tuán)，導(dǎo)致染色質(zhì)結(jié)構(gòu)緊縮，從而抑制特定基因的轉(zhuǎn)錄。HDAC1的活性受到多種信號通路的調(diào)控，包括Wnt信號通路和PKN1信號通路等。HDAC1參與了細(xì)胞周期、細(xì)胞分化、細(xì)胞凋亡等重要生理過程的調(diào)控。HDAC1的異常表達(dá)或活性改變與多種疾病的發(fā)生發(fā)展有關(guān)，尤其是與癌癥、神經(jīng)退行性疾病和心血管疾病等密切相關(guān)。HDAC1是組蛋白去乙酰化酶抑制劑（HDACi）的主要靶點(diǎn)之一，HDACi能夠通過抑制HDAC1的活性，調(diào)控細(xì)胞凋亡及分化相關(guān)蛋白的表達(dá)和穩(wěn)定性，誘導(dǎo)細(xì)胞凋亡及分化，成為一類新的抗腫瘤藥物。HDAC1的抑制劑在癌癥治療中的應(yīng)用前景廣闊，同時(shí)，HDAC1在免疫細(xì)胞功能調(diào)控及自身免疫病中的作用也受到了廣泛關(guān)注。
熱銷產(chǎn)品
Recombinant Human Histone deacetylase 1 (HDAC1) (CSB-EP010235HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP010235HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) HDAC1.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP010235HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) HDAC1.
HDAC1 Recombinant Monoclonal Antibody (CSB-RA299884A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate, Jurkat whole cell lysate, HL60 whole cell lysate
All lanes: HDAC1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 56 kDa
Observed band size: 60 kDa
HDAC1 Antibodies
HDAC1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA010235GA01HU | HDAC1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA599472 | Phospho-HDAC1 (Ser421) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA157026 | HDAC1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA002877 | HDAC1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA002913 | HDAC1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA005923 | HDAC1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA009171 | Phospho-HDAC1 (S421) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA192926 | HDAC1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA120655 | HDAC1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA278920 | HDAC1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA134980 | HDAC1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA17869A0Rb | HDAC1 Antibody | Human | ELISA, IHC, IF, ChIP |
| CSB-RA299884A0HU | HDAC1 Recombinant Monoclonal Antibody | Human | ELISA, WB |
HDAC1 Proteins
HDAC1 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010235CH CSB-EP010235CH CSB-BP010235CH CSB-MP010235CH CSB-EP010235CH-B |
Recombinant Chicken Histone deacetylase 1 (HDAC1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HDAC1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010235MO CSB-EP010235MO CSB-BP010235MO CSB-MP010235MO CSB-EP010235MO-B |
Recombinant Mouse Histone deacetylase 1 (Hdac1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HDAC1 Proteins for Strongylocentrotus purpuratus (Purple sea urchin)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010235FOT CSB-EP010235FOT CSB-BP010235FOT CSB-MP010235FOT CSB-EP010235FOT-B |
Recombinant Strongylocentrotus purpuratus Histone deacetylase 1 (HDAC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HDAC1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010235RA CSB-EP010235RA CSB-BP010235RA CSB-MP010235RA CSB-EP010235RA-B |
Recombinant Rat Histone deacetylase 1 (Hdac1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HDAC1 Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010235PYX CSB-EP010235PYX CSB-BP010235PYX CSB-MP010235PYX CSB-EP010235PYX-B |
Recombinant Pongo abelii Histone deacetylase 1 (HDAC1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HDAC1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010235HU CSB-BP010235HU CSB-MP010235HU CSB-EP010235HU-B |
Recombinant Human Histone deacetylase 1 (HDAC1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP010235HU | Recombinant Human Histone deacetylase 1 (HDAC1) | E.coli |
HDAC1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010235BO CSB-EP010235BO CSB-BP010235BO CSB-MP010235BO CSB-EP010235BO-B |
Recombinant Bovine Histone deacetylase 1 (HDAC1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
