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FTH1

FTH1,即鐵蛋白重鏈1,別名FHC、FTH、FTHL6、HFE5、PIG15、PLIF等。它廣泛來源于動物和植物細胞,是鐵蛋白的主要組成部分。FTH1能夠將機體內(nèi)的鐵離子催化成Fe3+并儲存,以維持正常的鐵穩(wěn)態(tài);具有亞鐵氧化酶活性,促進鐵的氧化和細胞對鐵的攝??;還具備抗氧化應激功能,能夠降解自由基,有效阻止由過量鐵引起的氧化損害。FTH1參與鐵代謝過程,包括鐵的吸收、轉運和利用,同時還參與免疫應答、細胞增殖等生理過程,并對細胞具有保護作用。FTH1還與多種疾病的發(fā)生相關,如鐵過載、神經(jīng)退行性疾病等,因此調控FTH1的表達可能是多種疾病潛在的治療靶點。

熱銷產(chǎn)品

Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active) (CSB-MP007479HU)

驗證數(shù)據(jù)

CSB-MP007479HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP007479HU

Based on the SEQUEST from database of Mammalian Cell host and target protein, the LC-MS/MS Analysis result of CSB-MP007479HU could indicate that this peptide derived from Mammalian Cell-expressed Homo sapiens (Human) EGFR.

CSB-MP007479HU

Based on the SEQUEST from database of Mammalian Cell host and target protein, the LC-MS/MS Analysis result of CSB-MP007479HU could indicate that this peptide derived from Mammalian Cell-expressed Homo sapiens (Human) EGFR.

CSB-MP007479HU

Measured by its binding ability in a functional ELISA. Immobilized EGFR at 1 μg/ml can bind Anti-EGFR recombinant antibody, the EC50 of human EGFR protein is 2.867-3.571 ng/ml.

CSB-MP007479HU

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

CSB-MP007479HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized EGFR at 1 μg/ml can bind Cetuximab, the EC50 of human EGFR protein is 0.6919-1.047 ng/ml.

CSB-MP007479HU

The purity of EGFR was greater than 95% as determined by SEC-HPLC

EGFR Recombinant Monoclonal Antibody (CSB-RA159341MA1HU)

驗證數(shù)據(jù)

CSB-RA159341MA1HU

IHC image of CSB-RA159341MA1HU diluted at 1:50 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA159341MA1HU

IHC image of CSB-RA159341MA1HU diluted at 1:50 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA159341MA1HU

Overlay Peak curve showing NIH/3T3 cells stained with CSB-RA159341MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Rabbit IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

FTH1 Antibodies

FTH1 for Homo sapiens (Human)

FTH1 Proteins

FTH1 Proteins for Sus scrofa (Pig)

FTH1 Proteins for Ovis aries (Sheep)

FTH1 Proteins for Oryctolagus cuniculus (Rabbit)

FTH1 Proteins for Homo sapiens (Human)

FTH1 Proteins for Mus musculus (Mouse)

FTH1 Proteins for Bos taurus (Bovine)

FTH1 Proteins for Rattus norvegicus (Rat)

FTH1 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

FTH1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

FTH1 Proteins for Felis catus (Cat) (Felis silvestris catus)

FTH1 Proteins for Pongo abelii (Sumatran orangutan)

FTH1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

FTH1 Proteins for Trichosurus vulpecula (Brush-tailed possum)

FTH1 ELISA Kit

FTH1 ELISA Kit for Mus musculus (Mouse)

FTH1 ELISA Kit for Sus scrofa (Pig)



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