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CTPS1

CTPS1,全稱為胞質胸苷酸合成酶1(Cytoplasmic Thymidylate Synthetase 1),是一種參與DNA合成的重要酶。它通過催化dCMP和dATP生成dTTP,為DNA復制提供必要的核苷三磷酸。CTPS1在細胞內廣泛表達,并在多種生理過程中發揮關鍵作用。由于其在DNA合成中的核心地位,CTPS1的異常表達或功能失調與多種疾病相關,包括癌癥、自身免疫性疾病和代謝性疾病。近年來,CTPS1成為藥物研發的熱點靶點。研究人員發現,抑制CTPS1可以減弱腫瘤細胞的增殖,從而為癌癥治療提供新的策略。此外,CTPS1抑制劑也被研究用于治療自身免疫性疾病和代謝性疾病。目前,已有多種CTPS1抑制劑進入臨床試驗階段,顯示出良好的治療效果。例如,Step Pharma公司開發的dencatistat是一種高選擇性、具有口服生物利用度的CTPS1抑制劑,正在開發用于治療癌癥和血液疾病。研究表明,dencatistat能夠有效抑制腫瘤細胞的增殖,并提高化療藥物的療效。此外,dencatistat在治療自身免疫性疾病方面也顯示出一定的潛力。總之,CTPS1是一種重要的酶,在DNA合成中發揮關鍵作用。由于其在多種疾病中的重要作用,CTPS1成為藥物研發的熱點靶點。目前,已有多種CTPS1抑制劑進入臨床試驗階段,顯示出良好的治療效果,為相關疾病的治療提供了新的希望。

熱銷產品

Recombinant Human CTP synthase 1 (CTPS1) (CSB-YP006176HU)

驗證數據

CSB-YP006176HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CTPS1 Recombinant Monoclonal Antibody (CSB-RA699717A0HU)

驗證數據

CSB-RA699717A0HU

Flow cytometric analysis of CTP synthase 1 expression in HT-1080 cells using CTP synthase 1 antibody. Green, isotype control; red, CTP synthase 1.

CSB-RA699717A0HU

Western blotting analysis using CTP synthase 1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with CTP synthase 1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.

CTPS1 Antibody (CSB-PA006176LA01HU)

驗證數據

CSB-PA006176LA01HU

Western blot
All lanes: CTPS1 antibody at 6µg/ml
Lane 1: Hela whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 67, 42 kDa
Observed band size: 67 kDa

CSB-PA006176LA01HU

Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA006176LA01HU at dilution of 1:100

CSB-PA006176LA01HU

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA006176LA01HU at dilution of 1:100

CTPS1 Antibodies

CTPS1 for Homo sapiens (Human)

CTPS1 Proteins

CTPS1 Proteins for Homo sapiens (Human)