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  4. CTPS1 Recombinant Monoclonal Antibody

CTPS1 Recombinant Monoclonal Antibody

  • 中文名稱：
    CTPS1 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA699717A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of CTP synthase 1 expression in HT-1080 cells using CTP synthase 1 antibody. Green, isotype control; red, CTP synthase 1.
    • Western blotting analysis using CTP synthase 1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with CTP synthase 1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CTPS1
  • 別名：
    CTPS1; CTP Synthase 1; GATD5A; CTPS; UTP--Ammonia Ligase 1; CTP Synthetase 1; EC 6.3.4.2; Cytidine 5-Prime Triphosphate Synthetase; Cytidine 5'-Triphosphate Synthetase; CTP Synthase; GATD5; IMD24
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human CTPS1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    21A12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.
  • 基因功能參考文獻：
    1. CTP synthase forms the cytoophidium in human hepatocellular carcinoma. PMID: 29097181
    2. The filament structures elucidate allosteric mechanisms of assembly and regulation that rely on a conserved conformational equilibrium. The findings may provide a mechanism for increasing human CTP synthase activity in response to metabolic state and challenge the assumption that metabolic filaments are generally storage forms of inactive enzymes. PMID: 28459447
    3. Rods and rings (RR) are protein assemblies composed of CTPS1 and IMPDH2. Glutamine deprivation initiates reversible assembly of mammalian rods and rings. PMID: 24477477
    4. results highlight a key and specific role of CTPS1 in the immune system by its capacity to sustain the proliferation of activated lymphocytes during the immune response PMID: 24870241
    5. analysis of the kinetic properties of hCTPS1 and hCTPS2, and determination that Ser(68) is a major site of CTPS2 regulation by phosphorylation PMID: 20739275
    6. CTP synthetase is phosphorylated by protein kinase A PMID: 16179339
    7. Data indicate that protein kinase C phosphorylation at Ser(462) stimulates human CTP synthetase 1 activity, whereas phosphorylation at Thr(455) inhibits activity. PMID: 17463002
    8. analysis of phosphorylation and regulation of human CTPS1 in human cells shows that GSK3 is a novel regulator of CTPS activity PMID: 17681942
    9. studies provide novel information on the potential interacting proteins that may regulate CTPS1 function or intracellular localization PMID: 18600551

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  • 相關疾病：
    Immunodeficiency 24 (IMD24)
  • 亞細胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    CTP synthase family
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 2519

    OMIM: 123860

    KEGG: hsa:1503

    STRING: 9606.ENSP00000361699

    UniGene: Hs.473087



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