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CA9

碳酸酐酶IX(CA9)是一種跨膜鋅金屬酶,又稱G250或MN蛋白,在維持細胞酸堿平衡中起關鍵作用。該蛋白通過催化二氧化碳水合反應調節腫瘤微環境pH值,其表達受缺氧誘導因子HIF-1α調控,在透明細胞腎癌中呈現特異性高表達,約95%患者存在CA9過表達現象。作為重要的腫瘤相關抗原,CA9不僅參與PI3K/AKT等促生存信號傳導,還與血管生成、腫瘤轉移密切相關,其表達水平與腎癌、宮頸癌等多種實體瘤不良預后顯著相關。目前針對CA9開發的單克隆抗體Girentuximab已完成III期臨床,用于腎癌的放射性免疫顯像診斷;小分子抑制劑SLC-0111作為首款進入臨床試驗的CAIX靶向藥物,在乳腺癌、胰腺癌等適應癥的II期研究中顯示出聯合化療增效潛力。近年來基于CA9的CAR-T療法和DNA疫苗也進入臨床前研究階段。

熱銷產品

Recombinant Human Carbonic anhydrase 9 (CA9), partial (CSB-EP614990HUc0)

驗證數據

CSB-EP614990HUc0

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP614990HUc0

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP614990HUc0 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CA9.

CSB-EP614990HUc0

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP614990HUc0 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CA9.

CA9 Recombinant Monoclonal Antibody (CSB-RA614990A0HU)

驗證數據

CSB-RA614990A0HU

IHC image of CSB-RA614990A0HU diluted at 1:118 and staining in paraffin-embedded human gastric cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-RA614990A0HU

IHC image of CSB-RA614990A0HU diluted at 1:118 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human Carbonic Anhydrase 9(CA9) ELISA Kit (CSB-E13266h)

驗證數據

CSB-E13266h 標準曲線

貨號:CSB-E13266h

規格:96T/48T

靈敏度:7.81 pg/mL

檢測范圍:31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CA9 Antibodies

CA9 for Homo sapiens (Human)

CA9 for H

CA9 Proteins

CA9 Proteins for Homo sapiens (Human)

CA9 Proteins for Mus musculus (Mouse)

CA9 ELISA Kit

CA9 ELISA Kit for Homo sapiens (Human)



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