ALOX5

ALOX5，即花生四烯酸5-脂氧合酶，別名Arachidonate 5-lipoxygenase。它屬于脂氧合酶家族成員，由人體細(xì)胞自身編碼產(chǎn)生。ALOX5在多種細(xì)胞類型中都有表達(dá)，特別是在骨髓衍生的細(xì)胞中表達(dá)量較高。其作用機(jī)制主要是催化花生四烯酸轉(zhuǎn)化為5(S)-HPETE，進(jìn)而生成白三烯A4（LTA4），這是白三烯生物合成途徑中的起始和關(guān)鍵步驟。白三烯是一類重要的炎癥介質(zhì)，參與多種炎癥和過敏反應(yīng)的調(diào)控。ALOX5的活性受到多種因素的調(diào)控，包括細(xì)胞因子、應(yīng)激反應(yīng)和細(xì)胞內(nèi)信號分子等。ALOX5在生物學(xué)上的意義主要體現(xiàn)在其對炎癥反應(yīng)的調(diào)控作用。它不僅參與了白三烯的合成，影響炎癥和免疫過程，還可能參與脂質(zhì)過氧化和細(xì)胞死亡模式的調(diào)控，如凋亡、焦亡和鐵死亡。ALOX5的表達(dá)或活性異常與多種疾病的發(fā)生發(fā)展有關(guān)，包括哮喘、動脈粥樣硬化、腫瘤等。此外，ALOX5還可能作為腫瘤免疫微環(huán)境中的一個重要因素，影響腫瘤的免疫細(xì)胞浸潤和免疫治療的效果，因此，它也是藥物開發(fā)和疾病治療中的一個潛在靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) (CSB-CF001625HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ALOX5 Recombinant Monoclonal Antibody (CSB-RA198316A0HU)

驗(yàn)證數(shù)據(jù)

IHC image of CSB-RA198316A0HU diluted at 1:100 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA198316A0HU diluted at 1:100 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

ALOX5 Antibody

ALOX5 Protein

ALOX5 ELISA Kit

ALOX5 Antibodies

ALOX5 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA001624GA01HU	ALOX5 Antibody	Human,Mouse	ELISA,IF
CSB-PA555261	Phospho-ALOX5 (Ser523) Antibody	Human,Rat	ELISA,WB
CSB-PA008470	Phospho-ALOX5 (S523) Antibody	Human,Rat	WB, ELISA
CSB-PA008472	Phospho-ALOX5 (S272) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA008474	ALOX5 Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA043268	ALOX5 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA787659	ALOX5 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA001624LA01HU	ALOX5 Antibody	Human	ELISA, IHC, IF
CSB-PA001624LB01HU	ALOX5 Antibody, HRP conjugated	Human	ELISA
CSB-RA198316A0HU	ALOX5 Recombinant Monoclonal Antibody	Human	ELISA, IHC

ALOX5 Proteins

ALOX5 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP001624RA CSB-EP001624RA CSB-BP001624RA CSB-MP001624RA CSB-EP001624RA-B	Recombinant Rat Arachidonate 5-lipoxygenase (Alox5)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ALOX5 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP001624MO CSB-EP001624MO CSB-BP001624MO CSB-MP001624MO CSB-EP001624MO-B	Recombinant Mouse Arachidonate 5-lipoxygenase (Alox5)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ALOX5 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP001624HU CSB-BP001624HU CSB-MP001624HU CSB-EP001624HU-B	Recombinant Human Arachidonate 5-lipoxygenase (ALOX5)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP001624HU	Recombinant Human Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)	E.coli
CSB-EP001624HUd7	Recombinant Human Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)	E.coli

ALOX5 Proteins for Mesocricetus auratus (Golden hamster)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP001624MRG CSB-EP001624MRG CSB-BP001624MRG CSB-MP001624MRG CSB-EP001624MRG-B	Recombinant Mesocricetus auratus Arachidonate 5-lipoxygenase (ALOX5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli