SIGLEC15 (NC-318 Biosimilar) Recombinant Monoclonal Antibody

產(chǎn)品詳情

Uniprot No.：

Q6ZMC9
基因名：

SIGLEC15
別名：

5G-12 research-grade biosimilar; NC 318 research-grade biosimilar ;SIGLEC15 antibody; CD33L3 antibody; Sialic acid-binding Ig-like lectin 15 antibody; Siglec-15 antibody; CD33 antigen-like 3 antibody
反應(yīng)種屬：

Human
免疫原：

Recombinant Human SIGLEC15 protein
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
克隆類型：

Monoclonal
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

0.01M PBS，pH7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用說明：

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

3-4 weeks
用途：

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

功能：

Binds sialylated glycoproteins.
基因功能參考文獻(xiàn)：
1. Siglec-15 recognizes the tumoral sTn antigen and transduces a signal for enhanced TGF-beta secretion in TAMs PMID: 23035012
亞細(xì)胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
組織特異性：

Expressed in macrophage and/or dendritic cells of spleen and lymph nodes.
數(shù)據(jù)庫鏈接：

HGNC: 27596

KEGG: hsa:284266

STRING: 9606.ENSP00000374125

UniGene: Hs.287692