Recombinant Pig Transferrin receptor protein 1 (TFRC), partial

中文名稱：

Recombinant Pig Transferrin receptor protein 1 (TFRC), partial
品名簡稱：

Recombinant Pig TFRC protein, partial
貨號：

CSB-MP816838PI1
說明書：

MSDS Datasheet
規格：

￥1536
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 95% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

TFRC
Uniprot No.：

Q8HZV3
別名：

TR; TfR; TfR1; Trfr;CD71
種屬：

Sus scrofa (Pig)
蛋白長度：

Partial
來源：

Mammalian cell
分子量：

79.9 kDa
表達區域：

90-768aa
氨基酸序列

AYCKRVESKTDCKTLVPTEPSETEETETFEAENFPQTPRLFWADLKILLSKGLDTTDFTRTIKMLNEDYAPREAGSQKDESLGFFIENQFREFKLSKVWHDEHFVKIQVKGSNAENSVTLVNTDSNSLVYPVESPEGYVAYSKATTVTGKLIFANFGTKKDFEDLKMPVNGSLVIVRAGKITFAEKVANAQSLDAIGVLIYMDRANFPIINADVPVFGHAHLGTGDPYTPGFPSFNHTQFPPSQSSGLPNIPVQTISRAGAEKLFGNMEQDCPLTWRTDFPCKLVSSPSKNVKLTVNNVLKEIKILNIFGVIKGFEEPDRYVIVGAQRDAWGPGAAKSSVGTSLLLNLAQILSDMVIKGQFKPSRSIVFASWSAGDFGAIGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYSLIEKMMQDVKNPVTGQSLYRDSNWINKVEKLSFDDAAFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYDVLSKRVPQLNRMARAAAEVAGHLVIKLTIDFELNLNYEMYNDKILSFVREMNQFRVDIREMGLSLQWLYSARGDFFRATSRLTSDYRNVETRDKFVMREINDRIMKVEYHFLSPYVSPRESPFRHIFWGSGSHTLSALVEHLKLRQKNSSAFNQTLLKNQLALATWTIQGAANALSGDIWDIDNEF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Positively regulates T and B cell proliferation through iron uptake. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion. When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2.
基因功能參考文獻：
1. Two polymorphisms are identified in a single exon aafter comparaative sequencing analysis. PMID: 17651325
亞細胞定位：

Cell membrane; Single-pass type II membrane protein. Melanosome.
蛋白家族：

Peptidase M28 family, M28B subfamily
數據庫鏈接：

KEGG: ssc:397062

STRING: 9823.ENSSSCP00000029501

UniGene: Ssc.38