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  4. Recombinant Mouse Parvalbumin alpha (Pvalb)

Recombinant Mouse Parvalbumin alpha (Pvalb)

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  • 中文名稱：
    小鼠Pvalb重組蛋白
  • 品名簡稱：
    Recombinant Mouse Pvalb protein
  • 貨號：
    CSB-EP019092MO
  • 說明書：
  • 規(guī)格：
    ￥2328
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    E.coli
  • 分子量：
    19.2 kDa
  • 表達區(qū)域：
    2-110aa
  • 氨基酸序列
    SMTDVLSAEDIKKAIGAFAAADSFDHKKFFQMVGLKKKNPDEVKKVFHILDKDKSGFIEEDELGSILKGFSSDARDLSAKETKTLLAAGDKDGDGKIGVEEFSTLVAES
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.
  • 基因功能參考文獻：
    1. Data indicate that fast-spiking interneurons which typically express parvalbumin (PV) show greater firing coherence with CA1 network oscillations. PMID: 28382952
    2. Martinotti cells in layers II/III of the mouse primary somatosensory cortex are inhibited by both parvalbumin (PV)- and vasoactive intestinal polypeptide (VIP)-expressing cells. PMID: 27897179
    3. Synapses from parvalbumin-expressing interneurons onto hippocampal pyramidal neurons are regulated by neuronal firing, signaling through L-type calcium channels. PMID: 29295931
    4. This study investigated the distribution of Ca2+-binding proteins (CaBPs), such as calbindin D28k, parvalbumin, and calretinin, in the Superior Olivary Complex of the circling mouse on postnatal day 16. PMID: 29130968
    5. Axotomy Leads to Reduced Calcium Increase and Upregulated Parvalbumin Followed by Decreased Neighboring Microglial Activation. PMID: 28017131
    6. reduction of PV(+) neurons was in all cases, i.e., in PV+/-, Shank1-/- and Shank3B-/- mice, was due to a reduction in Pvalb mRNA and PV protein PMID: 26819149
    7. The calcium-binding protein parvalbumin (PV) is a crucial marker in defining the most predominant interneuron subtype within the cerebral cortex. PMID: 26882036
    8. dysfunction of parvalbumin positive interneurons signaling in the prefrontal cortex (PFC) specifically produces deficits in the cognitive domain, but does not give rise to PFC-dependent correlates of negative or positive symptoms. PMID: 26608841
    9. Thus PV+ GP neurons are synaptically positioned to directly coordinate activity between BG input nuclei, the striatum and STN, and thalamic-output from the SNr. PMID: 26905595
    10. These findings confirm that fate determination of cortical interneurons subgroups is crucially influenced by Shh signaling, and provide a system for the further study of interneuron fate and function. PMID: 25804737
    11. Parvalbumin and Npas1 neurons have different topologies within the basal ganglia. PMID: 26311767
    12. Nearly all parvalbumin interneurons express Lynx1 did not detect Lypd6 in this population. Conversely, in somatostatin interneurons Lypd6 was found in a subset localized to deep cortical layers but no somatostatin neurons show detectable levels of Lynx1. PMID: 25359633
    13. Our data indicate that the injury-triggered up-regulation of PV-expression is mediated by inflammatory cytokines, and promotes the motility and adhesion of ependymal cells. PMID: 25421913
    14. There was a significant correlation between Y-maze performance and PV expression in the dorsal hippocampus in WT mice, but no such correlation in BDNF+/- mice. PMID: 25603414
    15. EF-hand Ca(2+) buffers regulate presynaptic IHC function for metabolically efficient sound coding. PMID: 25691754
    16. Fgfr1 inactivation in the mouse telencephalon results in impaired maturation of interneurons expressing parvalbumin. PMID: 25116473
    17. This study demonistrated that Early- and late-born parvalbumin basket cell subpopulations exhibiting distinct regulation and roles in learning. PMID: 25695271
    18. Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome. PMID: 25024183
    19. This study demonistrated that the developmental trajectory of parvalbumin- and calretinin-positive interneurons along the dorso-ventral and rostro-caudal axes of the ventral hippocampus in juvenile, adolescent, and adult rats. PMID: 23893875
    20. Suppression of excitatory parvalbumin-positive fast spiking interneurons in the prelimbic area may enhance reward-related behavioral flexibility. PMID: 24599468
    21. Parvalbumin tunes spike-timing and efferent short-term plasticity in striatal fast spiking interneurons. PMID: 23551945
    22. The results of this study suggested a niche mechanism involving parvalbumin interneurons that couples local circuit activity to the diametric regulation of two critical early phases of adult hippocampal neurogenesis. PMID: 24212671
    23. This study demonistrated that Parvalbumin-expressing inhibitory interneurons in auditory cortex are well-tuned for frequency in mice. PMID: 23966693
    24. These results suggest the fact that the maintenance of parvalbumin expression is mediated to the neuroprotective function of nicotinamide against ischemic brain injury. PMID: 23047329
    25. We failed to provide proof-of-concept evidence that lower PV and GAT1 expression in schizophrenia are a consequence of lower GAD67 expression PMID: 23103418
    26. The rapid spiking inhibitory interneurons that co-express PV are involved in shaping neural responses to fast spectrotemporal modulations. We examined cortical PV expression in the C57bl/6 mouse, a strain commonly studied as a presbycusis model. PMID: 23010334
    27. In a circling mouse model of deafness, there is a decrese in expression of parvalbumin in the hippocampus. PMID: 22226504
    28. Increase in NF-kappaB activation coincides with increased reactive oxygen species production and decreased parvalbumin expression in parvalbumin-interneurons in vitro. PMID: 21378588
    29. The results of this study indicated that PV cells are ideally suited to modulate cortical gain and establish a causal relationship between a select neuron type and specific computations performed by the cortex during sensory PMID: 22243754
    30. phenotype of mice with GABA(A) receptor gamma2 subunits from parvalbumin neurons PMID: 21912668
    31. Our work indicates that parvalbumin and the cannabinoid-1 (CB1) receptor might be far more intricately related than previously thought. PMID: 21445945
    32. The relative mean density of calbindin and parvalbumin immunoreactivity in the Purkinje cell layer is significantly decreased in the homozygous cir/cir genotype, compared with the wild-type. PMID: 20691752
    33. Data show that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory. PMID: 21278730
    34. These data provide more direct evidence of the protective role of parvalbumin against the degeneration mediated by a calcium increase in the acute injury of motor neurons. PMID: 20394052
    35. Data conclude that GPx4 is a selenoenzyme modulating interneuron function and parvalbumin expression. PMID: 19890015
    36. The expression of PV and its colocalization with neuronal nitric oxide synthase have been determined in different populations of hippocampal GABAergic neurons. PMID: 12115690
    37. Parvalbumin deficiency, due to an increased short-term facilitation of GABA release, enhances inhibition by high-frequency burst-firing PV-expressing interneurons and may affect the higher cognitive functions associated with gamma oscillations. PMID: 12626620
    38. The slight aggravation of muscle dystrophy observed in mdx mice deprived of parvalbumin cannot explain the severity of the affection observed in xmd dogs and Duchenne dystrophy patients where parvalbumin is constitutively not expressed. PMID: 12798793
    39. Distinct kinetics of parvalbumin and calbindin D28k underlie biphasic kinetics of synaptically evoked Ca2+ transients in dendritic shafts of Purkinje cells. PMID: 12813159
    40. This study conclude that alterations in the Ca(2+) homeostasis present in mice ectopically expressing neuronal PV are more deleterious under excitotoxic stress PMID: 14980812
    41. Parvalbumin arises as a major contributor to presynaptic Ca(i) signals and synaptic integration in the cerebellar cortex. PMID: 15634771
    42. Retinal illumination had opposite effects on levels of parvalbumin and oxytocin and decreased parvalbumin staining in the cilia. PMID: 15964694
    43. These results demonstrate that the absence of the parvalbumin disrupts the regulation of Purkinje cell firing rate and rhythmicity. PMID: 16115209
    44. Quantitative analysis of selected mitochondrial proteins revealed the PV-/- tibialis anterior mitochondria composition to be almost identical to that in wild-type soleus, but not in wild-type fast-twitch muscles. PMID: 16367751
    45. Density of parvalbumin-positive neurons does not alter during cortical plasticity in classical conditioning. PMID: 16413119
    46. Calcium-binding proteins may contribute to selective vulnerability and an early loss of function of large motor neurons in this SOD1-transgenic mouse model. PMID: 16546142
    47. In-strain embryo transfer had a differential influence on the numbers of amygdaloid parvalbumin-immunoreactive neurons of inbred C3H/HeN and DBA/2J mice. Maternal factors had a some impact on the numbers of PARV-ir neurons. PMID: 16860404
    48. The firing properties of four subtypes of parvalbumin-positive interneurons allow the neuron networks to perform an array of information-processing tasks within the basolateral amygdala. PMID: 17234587
    49. Analysis revealed a slightly increased activity in mice lacking parvalbumin as well as an increase in the characteristic speed during the first 8 day. PMID: 17275105
    50. Our results indicate that CB, PV and GABA show a dynamic pattern of colocalization in cells of the mouse basolateral amygdalar nucleus throughout development. PMID: 17681450

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  • 蛋白家族：
    Parvalbumin family
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:19293

    STRING: 10090.ENSMUSP00000005860

    UniGene: Mm.2766