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  4. Recombinant Mouse Bone morphogenetic protein 15 (Bmp15)

Recombinant Mouse Bone morphogenetic protein 15 (Bmp15)

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  • 中文名稱：
    Recombinant Mouse Bone morphogenetic protein 15 (Bmp15)
  • 品名簡稱：
    Recombinant Mouse Bmp15 protein
  • 貨號：
    CSB-EP002735MO
  • 說明書：
  • 規格：
    ￥1536
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產品詳情

  • 純度：
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    Bmp15
  • Uniprot No.：
  • 別名：
    Growth/differentiation factor 9B
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    E.coli
  • 分子量：
    20.9 kDa
  • 表達區域：
    268-392aa
  • 氨基酸序列
    QACSIESDASCPSQEHDGSVNNQCSLHPYKVSFHQLGWDHWIIAPRLYTPNYCKGICTRVLPYGLNSPNHAIIQSLVNELVNHSVPQPSCVPYNFLPMSILLIETNGSILYKEYEGMIAQSCTCR
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    C-terminal 6xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.
  • 基因功能參考文獻：
    1. these data provide evidence that the preovulatory LH surge leads to upregulation of several forms of BMP15 protein secreted by the oocyte for putative sequestration and/or interaction with ovarian follicular somatic cells. PMID: 24548471
    2. Data show that Rac1 induced nuclear import of STAT3 by physical binding, and nuclear STAT3 directly activated the transcription of essential oocyte-specific genes, including Jagged1, GDF9 and BMP15. PMID: 27050391
    3. results support a model of activation for human GDF9 dependent on cumulin formation through heterodimerization with BMP15. Oocyte-secreted cumulin is likely to be a central regulator of fertility in mono-ovular mammals. PMID: 26254468
    4. modified oocyte glycoproteins alter GDF9:BMP15 expression modifying follicle development resulting in the generation of more follicles PMID: 25416550
    5. findings that GDF9:BMP15 heterodimers are the most bioactive ligands in mice and humans compared with homodimers explain many puzzling genetic and physiological data and have important implications for improving female fertility in mammals PMID: 23382188
    6. show that purified mature regions of GDF9 and BMP15 synergistically interact in a specific manner which is not dependent on the presence of a pro-region. PMID: 21911477
    7. Integral role of GDF-9 and BMP-15 in ovarian function. PMID: 21226076
    8. oocyte-derived GDF9 and Bmp15 coordinate to promote the development of cumulus cells E2 and oocyte-derived paracrine factors GDF9 and bone morphogenetic protein 15 coordinate to promote the development of cumulus cells PMID: 21047911
    9. The results showed that both GDF-9 and BMP-15 were detectable in oocytes from primary follicles onward, besides, BMP-15 also presented in granulosa cells (GCs) and follicular follicle of mature follicles in mouse PMID: 20857181
    10. bone morphogenetic protein-15 could play a physiological role in the monotropic rise of FSH secretion by the pituitary during the estrous and menstrual cycle PMID: 12446622
    11. GCNF-dependent repression of Bmp15 mediates gamete regulation of female fertility. PMID: 12912906
    12. Bmp15 has a role in the development and function of the oocyte-cumulus cell complex in mice. PMID: 15531364
    13. Based on the biological role of BMP-15, defects in the production of mouse BMP-15 mature protein could correlate with the high ovulation quota and litter size observed in mice PMID: 15809424
    14. The functional mature form of BMP-15 is barely detectable in mouse oocytes until just before ovulation, when it is markedly increased. PMID: 16818886
    15. BMP15 levels increase during gonadotropin-induced follicular development, in parallel with oocyte maturation PMID: 16943361
    16. oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells. PMID: 17553902
    17. oocyte-derived paracrine factors, particularly, BMP15 and GDF9, promote cholesterol biosynthesis in cumulus cells, probably as compensation for oocyte deficiencies in cholesterol production PMID: 18045843
    18. RT-PCR data shows an increase in oogenesis specific gene transcripts (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) between the primordial until the preantral stages, with the exception of the Oogenesin1 transcripts under gonadotropin-induction. PMID: 19480014
    19. The highest Bmp15 mRNA levels were detected in oocytes in the pre-antral follicle stage. PMID: 19553355

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 組織特異性：
    Ovary specific.
  • 數據庫鏈接：