Recombinant Human Sorting nexin-12 (SNX12)

中文名稱：

人SNX12重組蛋白
貨號(hào)：

CSB-YP891787HU
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

人SNX12重組蛋白
貨號(hào)：

CSB-EP891787HU-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人SNX12重組蛋白
貨號(hào)：

CSB-BP891787HU
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

人SNX12重組蛋白
貨號(hào)：

CSB-MP891787HU
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

SNX12
Uniprot No.：

Q9UMY4
別名：

2610001F05Rik; AW045757; MGC118982; MGC118983; RGD1565585; RP23-356J7.1; SDP8; SNX 12; SNX12; SNX12_HUMAN; Sorting nexin 12; Sorting nexin-12
種屬：

Homo sapiens (Human)
蛋白長(zhǎng)度：

Full Length of Mature Protein
表達(dá)區(qū)域：

2-172
氨基酸序列

SDTAVADTR RLNSKPQDLT DAYGPPSNFL EIDIFNPQTV GVGRARFTTY EVRMRTNLPI FKLKESCVRR RYSDFEWLKN ELERDSKIVV PPLPGKALKR QLPFRGDEGI FEESFIEERR QGLEQFINKI AGHPLAQNER CLHMFLQEEA IDRNYVPGKS LAVSCPGWSA VA
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

May be involved in several stages of intracellular trafficking.
基因功能參考文獻(xiàn)：
1. SNX12 plays a key role in intraluminal vesicle formation and in the maturation of a subpopulation of early endosomes into late endosomes, thereby regulating selective endocytic transport of cargo for degradation. PMID: 28705836
2. SNX12 protein level is dramatically decreased in the brain of Alzheimer's disease patients as compared to that of controls. PMID: 22709416
3. find that overexpression of SNX12 restores the sorting process in an Hrs knockdown background. Altogether, our data show that despite lower expression level, SNX12 shares redundant functions with SNX3 in the biogenesis of multivesicular endosomes PMID: 22719997
4. Metallothionein deficient mice have a marked decrease in Snx12 during acute lung injury PMID: 16166738
亞細(xì)胞定位：

Membrane; Peripheral membrane protein; Cytoplasmic side.
蛋白家族：

Sorting nexin family
數(shù)據(jù)庫(kù)鏈接：

HGNC: 14976

OMIM: 300883

KEGG: hsa:29934

STRING: 9606.ENSP00000363392

UniGene: Hs.260750