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  4. Recombinant Human Rho GTPase-activating protein 31 (ARHGAP31), partial

Recombinant Human Rho GTPase-activating protein 31 (ARHGAP31), partial

  • 中文名稱：
    Recombinant Human Rho GTPase-activating protein 31(ARHGAP31) ,partial
  • 貨號：
    CSB-YP639872HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Rho GTPase-activating protein 31(ARHGAP31) ,partial
  • 貨號：
    CSB-EP639872HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Rho GTPase-activating protein 31(ARHGAP31) ,partial
  • 貨號：
    CSB-EP639872HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Rho GTPase-activating protein 31(ARHGAP31) ,partial
  • 貨號：
    CSB-BP639872HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Rho GTPase-activating protein 31(ARHGAP31) ,partial
  • 貨號：
    CSB-MP639872HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ARHGAP31
  • Uniprot No.：
  • 別名：
    ARHGAP31; CDGAP; KIAA1204; Rho GTPase-activating protein 31; Cdc42 GTPase-activating protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration.
  • 基因功能參考文獻：
    1. Study demonstrate that CdGAP acts as a novel co-transcriptional repressor with Zeb2 to suppress E-cadherin expression in breast cancer cells. PMID: 28135249
    2. a four-generation pedigree with isolated terminal limb defects and a truncating mutation in ARHGAP31 underscores the relevance of sequencing ARHGAP31 in cases of isolated limb defects, irrespective of presence of a complete Adams-Oliver syndrome phenotype PMID: 24668619
    3. The focal adhesion-localized CdGAP regulates matrix rigidity sensing and durotaxis. PMID: 24632816
    4. Data demonstrate that cdGAP negatively regulates directed and random migration by controlling adhesion maturation and dynamics through the regulation of both adhesion assembly and disassembly. PMID: 22907917
    5. specific interaction between negatively charged phospholipid PI(3,4,5)P3 and the stretch of polybasic residues preceding the RhoGAP domain regulates CdGAP activity in vivo and is required for its cellular functions. PMID: 22518840
    6. Rho GTPase activating protein 31 PMID: 21774070
    7. Our findings demonstrate that heterozygous gain-of-function mutations in ARHGAP31 cause an autosomal-dominant form of ACC-TTLD through introduction of premature termination codons in the terminal exon of the gene. PMID: 21565291
    8. Results suggest that CdGAP may play an unexpected role in apoptosis. PMID: 16519628
    9. CdGAP is a novel glycogen synthase kinase 3alpha (GSK-3alpha) substrate. PMID: 17158447

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  • 相關疾病：
    Adams-Oliver syndrome 1 (AOS1)
  • 亞細胞定位：
    Cell projection, lamellipodium. Cell junction, focal adhesion.
  • 數據庫鏈接：

    HGNC: 29216

    OMIM: 100300

    KEGG: hsa:57514

    STRING: 9606.ENSP00000264245

    UniGene: Hs.668218