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  4. Recombinant Human Kinesin light chain 1 (KLC1)

Recombinant Human Kinesin light chain 1 (KLC1)

  • 貨號：
    CSB-YP012379HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 貨號：
    CSB-EP012379HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 貨號：
    CSB-EP012379HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 貨號：
    CSB-BP012379HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 貨號：
    CSB-MP012379HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    KLC1
  • Uniprot No.：
  • 別名：
    Kinesin light chain 1; KLC 1; KLC1 KLC KNS2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length
  • 表達區域：
    1-573
  • 氨基酸序列
    MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGEEVSMSVEWNGGVSGRASFCGKRQQQQWPGRRHR
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
  • 基因功能參考文獻：
    1. structural plasticity of the N-terminal capping helix might represent a structural determinant for TPR domain structural versatility in cargo binding PMID: 29036226
    2. All binary complexes (KLC1:APP, KLC1:JIP1, and APP:JIP1) contain conformations with favorable binding free energies indicating that KLC1 and JIP1 may take part in APP transport in Alzheimer's disease patients. PMID: 27891669
    3. BNIP-2 is a kinesin-1 adapter involved in vesicular transportation in the cytoplasm and that association with cargos depends on interaction of the CRAL-TRIO domain with membrane phosphatidylserine. PMID: 25472445
    4. The G allele and GG genotype of KLC1 rs8702 were significantly over-represented among cataract patients, as compared to healthy controls, and were associated with an odds ratio for cataract development. PMID: 25883527
    5. Dnm1L interacts with KLC1 through the tetratricopeptide repeat domains. PMID: 25082190
    6. Microtubule-bound kinesin-1 and kinesin-3 motor domains were visualized at multiple steps in their ATPase cycles--including their nucleotide-free states--at approximately 7 A resolution using cryo-electron microscopy. PMID: 25209998
    7. Studies indicate that FEZ1 (fasciculation and elongation protein zeta 1), SCOCO (short coiled-coil protein) and kinesins (kinesin heavy chain) are involved in biological transport process. PMID: 24116125
    8. The expression levels of KLC1 variant E in brain and lymphocytes were significantly higher in Alzheimer's disease patients. PMID: 24497505
    9. study provides evidence that the combined effect of three variants within the KLC1 gene may predispose to age-related cataract. PMID: 23776437
    10. For the binding of cargos shared by KLC1, we propose a different site located within the groove but not involving N343. PMID: 22470497
    11. Data suggest that KLC1 is required for normal neural differentiation, ensuring proper metabolism of AD-associated molecules APP and Tau and for proliferation of neural precursors (NPs). PMID: 22272245
    12. Phosphorylation of KLC1 at serine 460 modulates binding and trafficking of calsyntenin-1. PMID: 21385839
    13. Results do not convincingly support kinesin light chain 1 (KLC1) as a major susceptibility gene in any of the studied diseases, although there is a small effect of KLC1 in relation to cataract. PMID: 19911314
    14. The major binding site for kinesin light chain in kinesin heavy chain has been mapped to residues 789-813 at the C-terminal end of the heavy chain stalk domain. PMID: 12475239
    15. For a single nucleotide polymorphism (G58836C in intron 13) in the kinesin light-chain 1 (KNS2) gene, the association between Alzheimer's disease and the C allele is found to be significant. PMID: 15364413
    16. KNS2 gene may play a role during early stages of Alzheimer's disease pathogenesis. PMID: 17611642
    17. KLC1 gene may be a novel susceptibility gene for age-related cataract. PMID: 17653041
    18. microtubule-dependent functions of von Hippel-Lindau tumour suppressor are influenced by kinesin-2 PMID: 17825299
    19. The present finding supports the involvement of the cytoskeleton and KNS2 in the development of vascular white matter damage, thereby opening up novel fields in the research into leukariois. PMID: 17977659
    20. The KLC1 56836CC variant exerts a significant protective effect on the occurrence of multiple sclerosis. PMID: 17999208
    21. The rs8702 variant of the kinesin light chain 1 genotype proved to exert strong amplifying effects on the occurrence and severity of leukoaraiosis in patients with long-lasting poorly controlled severe hypertension PMID: 19046961

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  • 亞細胞定位：
    Cell projection, growth cone. Cytoplasmic vesicle. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Kinesin light chain family
  • 組織特異性：
    Found in a variety of tissues. Mostly abundant in brain and spine.
  • 數據庫鏈接：

    HGNC: 6387

    OMIM: 600025

    KEGG: hsa:3831

    STRING: 9606.ENSP00000414982

    UniGene: Hs.20107



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