国产午夜福利片1000无码丨人妻国产成人久久av免费高清丨午夜做受视频试看6次丨日韩av不卡一区在线免费观看丨在线观看精品三级欧美

Your Good Partner in Biology Research

KLC1 Recombinant Monoclonal Antibody

  • 中文名稱:
    KLC1 Recombinant Monoclonal Antibody
  • 貨號:
    CSB-RA137932A0HU
  • 規格:
    ¥1320
  • 圖片:
    • Immunocytochemical staining of HepG2 cells with Kinesin light chain 1 antibody. Nuclei were stained blue with DAPI; Kinesin light chain 1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Flow cytometric analysis of Kinesin light chain 1 expression in HepG2 cells using Kinesin light chain 1 antibody. Green, isotype control; red, Kinesin light chain 1.
    • Western blotting analysis using Kinesin light chain 1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with Kinesin light chain 1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    KLC1
  • 別名:
    KLC1; Kinesin Light Chain 1; KLC; KNS2A; KNS2; Kinesin 2 60/70kDa; HKLC1S; HKLC1N; HKLC1P; HKLC1G; HKLC1R; HKLC1J; HKLC1B; Medulloblastoma Antigen MU-MB-2.50; Kinesin 2; KLC
  • 反應種屬:
    Human, Mouse, Rat
  • 免疫原:
    Recombinant Human KLC1 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    Rabbit IgG
  • 純化方式:
    Affinity-chromatography
  • 克隆號:
    10B11
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, FC, ICC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
  • 基因功能參考文獻:
    1. structural plasticity of the N-terminal capping helix might represent a structural determinant for TPR domain structural versatility in cargo binding PMID: 29036226
    2. All binary complexes (KLC1:APP, KLC1:JIP1, and APP:JIP1) contain conformations with favorable binding free energies indicating that KLC1 and JIP1 may take part in APP transport in Alzheimer's disease patients. PMID: 27891669
    3. BNIP-2 is a kinesin-1 adapter involved in vesicular transportation in the cytoplasm and that association with cargos depends on interaction of the CRAL-TRIO domain with membrane phosphatidylserine. PMID: 25472445
    4. The G allele and GG genotype of KLC1 rs8702 were significantly over-represented among cataract patients, as compared to healthy controls, and were associated with an odds ratio for cataract development. PMID: 25883527
    5. Dnm1L interacts with KLC1 through the tetratricopeptide repeat domains. PMID: 25082190
    6. Microtubule-bound kinesin-1 and kinesin-3 motor domains were visualized at multiple steps in their ATPase cycles--including their nucleotide-free states--at approximately 7 A resolution using cryo-electron microscopy. PMID: 25209998
    7. Studies indicate that FEZ1 (fasciculation and elongation protein zeta 1), SCOCO (short coiled-coil protein) and kinesins (kinesin heavy chain) are involved in biological transport process. PMID: 24116125
    8. The expression levels of KLC1 variant E in brain and lymphocytes were significantly higher in Alzheimer's disease patients. PMID: 24497505
    9. study provides evidence that the combined effect of three variants within the KLC1 gene may predispose to age-related cataract. PMID: 23776437
    10. For the binding of cargos shared by KLC1, we propose a different site located within the groove but not involving N343. PMID: 22470497
    11. Data suggest that KLC1 is required for normal neural differentiation, ensuring proper metabolism of AD-associated molecules APP and Tau and for proliferation of neural precursors (NPs). PMID: 22272245
    12. Phosphorylation of KLC1 at serine 460 modulates binding and trafficking of calsyntenin-1. PMID: 21385839
    13. Results do not convincingly support kinesin light chain 1 (KLC1) as a major susceptibility gene in any of the studied diseases, although there is a small effect of KLC1 in relation to cataract. PMID: 19911314
    14. The major binding site for kinesin light chain in kinesin heavy chain has been mapped to residues 789-813 at the C-terminal end of the heavy chain stalk domain. PMID: 12475239
    15. For a single nucleotide polymorphism (G58836C in intron 13) in the kinesin light-chain 1 (KNS2) gene, the association between Alzheimer's disease and the C allele is found to be significant. PMID: 15364413
    16. KNS2 gene may play a role during early stages of Alzheimer's disease pathogenesis. PMID: 17611642
    17. KLC1 gene may be a novel susceptibility gene for age-related cataract. PMID: 17653041
    18. microtubule-dependent functions of von Hippel-Lindau tumour suppressor are influenced by kinesin-2 PMID: 17825299
    19. The present finding supports the involvement of the cytoskeleton and KNS2 in the development of vascular white matter damage, thereby opening up novel fields in the research into leukariois. PMID: 17977659
    20. The KLC1 56836CC variant exerts a significant protective effect on the occurrence of multiple sclerosis. PMID: 17999208
    21. The rs8702 variant of the kinesin light chain 1 genotype proved to exert strong amplifying effects on the occurrence and severity of leukoaraiosis in patients with long-lasting poorly controlled severe hypertension PMID: 19046961

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell projection, growth cone. Cytoplasmic vesicle. Cytoplasm, cytoskeleton.
  • 蛋白家族:
    Kinesin light chain family
  • 組織特異性:
    Found in a variety of tissues. Mostly abundant in brain and spine.
  • 數據庫鏈接:

    HGNC: 6387

    OMIM: 600025

    KEGG: hsa:3831

    STRING: 9606.ENSP00000414982

    UniGene: Hs.20107



主站蜘蛛池模板: 玉环县| 来凤县| 枣强县| 乐都县| 宁远县| 岫岩| 得荣县| 高密市| 包头市| 郸城县| 宁陵县| 和龙市| 喀什市| 肃宁县| 石泉县| 浦县| 松桃| 大理市| 资溪县| 贵德县| 全南县| 军事| 孟连| 宜兰市| 高雄市| 张家川| 北宁市| 富锦市| 朝阳市| 德江县| 韶山市| 长垣县| 苗栗市| 东阳市| 福泉市| 蛟河市| 洪泽县| 巴南区| 当雄县| 元氏县| 广河县|