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  4. Recombinant Human Adhesion G protein-coupled receptor L3 (ADGRL3), partial

Recombinant Human Adhesion G protein-coupled receptor L3 (ADGRL3), partial

  • 中文名稱：
    Recombinant Human Adhesion G protein-coupled receptor L3 (ADGRL3), partial
  • 品名簡稱：
    Recombinant Human ADGRL3 protein, partial
  • 貨號：
    CSB-YP867185HUc7
  • 說明書：
  • 規(guī)格：
    ￥1656
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
  • Uniprot No.：
  • 別名：
    Calcium-independent alpha-latrotoxin receptor 3;Latrophilin-3;Lectomedin-3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 來源：
    Homo sapiens (Human)
  • 分子量：
    47.6 kDa
  • 表達(dá)區(qū)域：
    20-425aa
  • 氨基酸序列
    FSRAPIPMAVVRRELSCESYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENIRCYLPDAYKIMSQRCNNRTQCAVVAGPDVFPDPCPGTYKYLEVQYECVPYKVEQKVFLCPGLLKGVYQSEHLFESDHQSGAWCKDPLQASDKIYYMPWTPYRTDTLTEYSSKDDFIAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERTRNIVKFDLRTRIKSGEAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGKIVISQLNPYTLRIEGTWDTAYDKRSASNAFMICGILYVVKSVYEDDDNEATGNKIDYIYNTDQSKDSLVDVPFPNSYQYIAAVDYNPRDNLLYVWNNYHVVKYSLDFGPLDSRSGQAHHGQVSYISPPIHLDSELERPSVK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    C-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.
  • 基因功能參考文獻(xiàn)：
    1. An ultraconserved brain-specific enhancer within LPHN3 is associated with ADHD susceptibility. PMID: 27692237
    2. Associations between LPHN1 and LPHN3 polymorphisms and severity of bronchial hyper-responsiveness in asthmatics were conducted; however, no associations were found. PMID: 27325752
    3. Results suggest that UNC5 and LPHN3 can simultaneously bind to FLRT3, forming a trimeric complex, and that FLRT3 may form transsynaptic complexes with both LPHN3 and UNC5. PMID: 26235030
    4. LPHN3 confers ADHD susceptibility, and moderates methylphenidate treatment response in children and adolescents with ADHD. PMID: 25989180
    5. Study examined the association between the LPHN3 rs6551665 A/G polymorphism and Attention deficit hyperactivity disorder (ADHD) in Korea; samples used in the study consisted of 150 ADHD children and 322 controls; ADHD children appeared to have a surplus of GG genotype, studies with larger sample sizes needed. PMID: 25871512
    6. genetic association studies in Germany: Data suggest that, within a sample of patients with attention deficit disorder hyperactivity, SNPs in LPHN3 gene impacts behavioral and neurophysiological measures of cognitive response control. PMID: 23245769
    7. Increased LPHN3 mRNA expression levels correlated with axillary-node metastasis in breast cancer. PMID: 23317273
    8. The influence of LPHN3 genotype on attention deficit-hyperactivity disorder (ADHD) and addiction is mediated through alterations in transgenic monoamine signaling. PMID: 22575564
    9. A two-locus genetic interaction between LPHN3 and 11q predicts ADHD severity and long-term outcome. PMID: 22832519
    10. This study identifying loci for aADHD and led to the identification of LPHN3 as novel genes associated with ADHD across the lifespan. PMID: 22105624
    11. highly significant interaction between four SNPs and maternal stress during pregnancy and development of attention-deficit/hyperactivity disorder PMID: 22486528
    12. single-nucleotide polymorphisms harbored in the LPHN3 gene interact with SNPs spanning the 11q region that contains DRD2 and NCAM1 genes, to double the risk of developing ADHD. PMID: 21606926
    13. This study demonistrated that LPHN3 and its ligand FLRT3 play an important role in glutamatergic synapse development. PMID: 22405201
    14. LPHN3, a new gene in which variants have recently been shown to be associated with adhd. PMID: 21432600
    15. These results further support the LPHN3 contribution to combined type ADHD, and specifically to the persistent form of the disorder PMID: 21040458
    16. The mutational analysis of the entire coding region of LPHN3 in a cohort of 139 attention deficit hyperactivity disorder subjects and 52 controls, is reported. PMID: 21184580

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell junction.
  • 蛋白家族：
    G-protein coupled receptor 2 family, LN-TM7 subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20974

    OMIM: 616417

    KEGG: hsa:23284

    STRING: 9606.ENSP00000422533

    UniGene: Hs.28391