国产午夜福利片1000无码丨人妻国产成人久久av免费高清丨午夜做受视频试看6次丨日韩av不卡一区在线免费观看丨在线观看精品三级欧美

Your Good Partner in Biology Research

Recombinant Dog Transferrin receptor protein 1 (TFRC), partial

  • 中文名稱:
    Recombinant Dog Transferrin receptor protein 1 (TFRC), partial
  • 品名簡稱:
    Recombinant Dog TFRC protein, partial
  • 貨號:
    CSB-MP867082DO1
  • 說明書:
  • 規格:
    ¥1536
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    TR; TfR; TfR1; Trfr;CD71
  • 種屬:
    Canis lupus familiaris (Dog)
  • 蛋白長度:
    Partial
  • 來源:
    Mammalian cell
  • 分子量:
    80.3 kDa
  • 表達區域:
    91-770aa
  • 氨基酸序列
    YCKRVEPKAGCERPTGTEALGTERTEPSETEEYFPETPSRLFWTDLKTMLSERLSNTDFTNTMRWLNENSYVPREAGSQKDESLALLIENRFREFQLSKSWRDEHFVEIQVKSSNAQNTVTIVDMESDLVYLAESPEGYVAYSKATTVTGRLVHVNFGTKKDFENLKSPVNGSLVIARAGKITFAEKVANAQSYNALGVLIYMDQARFPIVNARIPFFGHAHLGTGDPYTPGFPSFNHTQFPPSQSSGLPSIPVQTISRAAAEKLFENMEGDCPSAWEIDPSCRLETSSNKNVNLTVNNVLKEIRIFNVFGVIKGFEEPDRYVVIGAQRDAWGPGAAKSSVGTALLLELARIFSDMVLKGGFKPSRSIVFASWSAGDFGAIGATEWLEGYLSSLHLKAFTYINLDKAILGTSNFKVSASPLLYSLLEKTMKDVKHPITGQSLYRDSNWINKVEKLSLDNAAFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDLYENLNQKIPQLNKMARGAAEVAGQLIMKLTYDLELNLNYEMYNDRILSFVRDMNQFRTDIKEMGLNLQWLYSARGDFFRATSRLTTDYKNAERTNRFVMREINDRIMKVEHNFLSPYVSPRDSPFRHIFWGSGSHTLPALVEHLKLRQKNKSAFNETLLRNQLALATWTIQGAANALSGDIWDIDNEF
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Positively regulates T and B cell proliferation through iron uptake. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion. When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2.
  • 基因功能參考文獻:
    1. sTfR significantly inhibited CPV infection of cultured feline F81 cells and decreased the mortality of CPV-infected dogs, which indicates that the sTfR has the anti-CPV activity both in vitro and in vivo PMID: 24089666
    2. The kinesin KIF16B mediates apical transcytosis of transferrin receptor in AP-1B-deficient epithelia. PMID: 23749212
    3. binds to CPV-2 or CPV-2b but only to very low levels, and does not bind FPV capsids PMID: 16912298
    4. comparison of the abilities of TfR1 orthologs from different species to support arenavirus entry found that the human and feline receptors were able to enhance entry of the pathogenic strains, but that neither the murine or canine forms were functional. PMID: 18003730
  • 亞細胞定位:
    Cell membrane; Single-pass type II membrane protein. Melanosome.
  • 蛋白家族:
    Peptidase M28 family, M28B subfamily
  • 數據庫鏈接:


主站蜘蛛池模板: 沙湾县| 平果县| 留坝县| 乌海市| 安阳县| 钦州市| 股票| 读书| 凌源市| 烟台市| 新郑市| 湖北省| 乌拉特后旗| 博白县| 白城市| 陇川县| 钟山县| 海原县| 盘山县| 北票市| 曲周县| 平山县| 泰来县| 东辽县| 兴业县| 大安市| 布拖县| 福建省| 常熟市| 潜江市| 清水河县| 静安区| 黄大仙区| 奉新县| 尼玛县| 滕州市| 肥西县| 南丹县| 德化县| 海伦市| 安阳县|