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  4. VAMP1 Recombinant Monoclonal Antibody

VAMP1 Recombinant Monoclonal Antibody

  • 中文名稱：
    VAMP1 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA080928A0HU
  • 規格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA080928A0HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    VAMP1
  • 別名：
    DKFZp686H12131 antibody; SYB 1 antibody; SYB1 antibody; Synaptobrevin 1 antibody; Synaptobrevin-1 antibody; Synaptobrevin1 antibody; VAMP 1 antibody; VAMP-1 antibody; Vamp1 antibody; VAMP1_HUMAN antibody; Vesicle associated membrane protein 1 antibody; Vesicle associated membrane protein 1 synaptobrevin 1 antibody; Vesicle-associated membrane protein 1 antibody
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide from human VAMP1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    25H6
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in the targeting and/or fusion of transport vesicles to their target membrane.
  • 基因功能參考文獻：
    1. VAMP1 homozygous mutations causes of presynaptic congenital myasthenic syndrome. PMID: 28253535
    2. residue 48 of VAMP1 varies frequently between M and I across seventeen closely related primate species, suggesting a potential selective pressure from members of BoNTs for resistance in vertebrates. PMID: 25010769
    3. Genetically regulated VAMP1 expression in the brain may modify both Alzheimer's disease risk and may contribute to Alzheimer's pathophysiology PMID: 25881291
    4. This report identifies vesicle-associated membrane protein 1 (VAMP1), which encodes a critical protein for synaptic exocytosis, as the responsible gene fora dominantly inherited spastic ataxia PMID: 22958904
    5. multiple domains outside the R-SNARE of tomosyn are critical to the efficacy of inhibition by tomosyn on exocytotic secretion PMID: 21330375

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  • 相關疾病：
    Spastic ataxia 1, autosomal dominant (SPAX1)
  • 亞細胞定位：
    [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome.; [Isoform 2]: Cytoplasmic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome.; [Isoform 3]: Mitochondrion outer membrane; Single-pass type IV membrane protein.
  • 蛋白家族：
    Synaptobrevin family
  • 組織特異性：
    Nervous system, skeletal muscle and adipose tissue.
  • 數據庫鏈接：

    HGNC: 12642

    OMIM: 108600

    KEGG: hsa:6843

    STRING: 9606.ENSP00000379602

    UniGene: Hs.20021