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  4. USO1 Recombinant Monoclonal Antibody

USO1 Recombinant Monoclonal Antibody

  • 中文名稱：
    USO1 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA272467A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of USO1 expression in HepG2 cells using USO1 antibody. Green, isotype control; red, USO1.
    • Immunocytochemical staining of HepG2 cells with USO1 antibody. Nuclei were stained blue with DAPI; USO1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using USO1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with USO1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    USO1
  • 別名：
    USO1; USO1 Vesicle Transport Factor; TAP; VDP; P115; General Vesicular Transport Factor P115; Transcytosis Associated Protein; USO1 Homolog, Vesicle Docking Protein (Yeast); USO1 Vesicle Docking Protein Homolog (Yeast); USO1 Vesicle Docking Protein Homolog; Transcytosis-Associated Protein; Vesicle Docking Protein P115; Vesicle Docking Protein; Vesicle-Docking Protein; Protein USO1 Homolog
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human USO1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    19H1
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.
  • 基因功能參考文獻：
    1. USO1 gene may be a promising target for the therapy of human multiple myeloma and its diagnosis marker. PMID: 26898451
    2. USO1 gene has a critical role in human colon cancer: USO1 is involved in cell proliferation and cell migration of colon cancer cells. PMID: 26184508
    3. P115 promotes proliferation of gastric cancer cells through an interaction with MIF. PMID: 24379579
    4. Scyl1 interacts with 58K/formiminotransferase cyclodeaminase (FTCD) and golgin p115, and is required for the maintenance of Golgi morphology. PMID: 20209057
    5. p115 plays a critical role in mitosis progression, implicating it as the only known golgin to regulate both mitosis and apoptosis PMID: 21536679
    6. a conserved tethering function of the Golgi protein p115 CTF which promotes p53-ERK interaction for the amplification of the apoptotic signal. PMID: 21147777
    7. Data show that the number of tandem ARM repeats in an ARM fold ranges from 6 to 12. PMID: 20126549
    8. Data show that p115 degradation plays a key role in amplifying the apoptotic response independently of Golgi fragmentation. PMID: 12438416
    9. p115 acts directly, rather than via a tether, to catalyze trans-SNARE complex formation preceding membrane fusion. PMID: 14736916
    10. The results suggest that p115 is involved in vesicular transport between endoplasmic reticulum and the Golgi, along with microtubule networks. PMID: 16256943
    11. The interaction between p115 and Cog2 was found to be essential for Golgi ribbon reformation after the disruption of the ribbon by p115 KD or brefeldin A treatment and recovery by re-expression of p115 or drug wash out, respectively. PMID: 17274799
    12. Golgi organization depends on mutually interacting domains in betaCOP and p115, suggesting that vesicle tethering at the Golgi involves p115 binding to the COPI coat PMID: 18434597
    13. nuclear import of the p115 CTF is required for it to stimulate the apoptotic response and suggest that its mode of action is confined to the nucleus. PMID: 19028683
    14. terminal repeat folds into the armadillo superhelical groove and allows homodimeric association with important implications for p115 mediated multiple protein interactions and tethering PMID: 19247479
    15. p115 is a critical intermediary component in the regulated secretion of MIF from monocytes/macrophages PMID: 19454686

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  • 亞細胞定位：
    Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein.
  • 蛋白家族：
    VDP/USO1/EDE1 family
  • 數據庫鏈接：

    HGNC: 30904

    OMIM: 603344

    KEGG: hsa:8615

    UniGene: Hs.744877