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  4. KIF22 Recombinant Monoclonal Antibody

KIF22 Recombinant Monoclonal Antibody

  • 中文名稱：
    KIF22 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA144792A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Western blotting analysis using phospho-KIF22 (S427) antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with phospho-KIF22 (S427) antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    KIF22
  • 別名：
    KIF22; Kinesin Family Member 22; OBP-1; OBP-2; KNSL4; Kid; Kinesin-Like Protein KIF22; Kinesin-Like Protein 4; Origin Of Plasmid DNA Replication-Binding Protein; Kinesin-Like DNA-Binding Protein Pseudogene; Kinesin-Like DNA-Binding Protein; OriP Binding Protein; Kinesin-Like 4; A-328A3.2; SEMDJL2; OBP; KID
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human KIF22 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    12F10
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells.
  • 基因功能參考文獻：
    1. Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules. PMID: 25743205
    2. we conclude that inhibition of KIF22 suppresses cancer cell proliferation by delaying mitotic exit through the transcriptional upregulation of CDC25C. PMID: 24626146
    3. Whole-exome sequencing identifies mutations of KIF22 in spondyloepimetaphyseal dysplasia with joint laxity, leptodactylic type PMID: 22152677
    4. Recurrent dominant mutations affecting two adjacent residues in the motor domain of the monomeric kinesin KIF22 result in skeletal dysplasia and joint laxity PMID: 22152678
    5. in all breast tumor tissues analyzed, variations in the Kid/KIF22 mRNA levels mirrored those seen with SIAH-1 mRNAs. PMID: 20144232
    6. These results are consistent with Kid having a role in chromosome congression in vivo, where it would be responsible for the polar ejection forces acting on the chromosome arms. PMID: 12606572
    7. its molecular structure and interaction with microtubules PMID: 12692123
    8. These results suggest that distinct from its role in chromosome movement, Kid contributes to spindle morphogenesis by mediating spindle microtubules stabilization. PMID: 16176979
    9. human Aurora B and Kid are identified as APC/C(Cdh1) substrates PMID: 17726374
    10. Association of importin-beta and -alpha with hKid triggers the initial targeting of hKid to mitotic chromosomes; local Ran-GTP-mediated cargo release promotes the accumulation of hKid on chromosomes. PMID: 18268099
    11. These data suggest that Kid-mediated anaphase/telophase chromosome compaction prevents formation of multinucleated cells. PMID: 18329364

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  • 相關疾病：
    Spondyloepimetaphyseal dysplasia with joint laxity, 2 (SEMDJL2)
  • 亞細胞定位：
    Nucleus. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
  • 組織特異性：
    Expressed in bone, cartilage, joint capsule, ligament, skin, and primary cultured chondrocytes.
  • 數據庫鏈接：

    HGNC: 6391

    OMIM: 603213

    KEGG: hsa:3835

    STRING: 9606.ENSP00000160827

    UniGene: Hs.612151



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