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KIF22 Antibody, Biotin conjugated

  • 中文名稱:
    KIF22兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA619894LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) KIF22 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KIF22
  • 別名:
    A 328A3.2 antibody; KID antibody; KIF 22 antibody; kif22 antibody; KIF22_HUMAN antibody; Kinesin family member 22 antibody; Kinesin like 4 antibody; Kinesin like DNA binding protein antibody; Kinesin like DNA binding protein pseudogene antibody; Kinesin like protein 4 antibody; Kinesin like protein KIF22 antibody; Kinesin-like DNA-binding protein antibody; Kinesin-like protein 4 antibody; Kinesin-like protein KIF22 antibody; KNSL 4 antibody; KNSL4 antibody; OBP 1 antibody; OBP 2 antibody; OBP antibody; OBP1 antibody; OBP2 antibody; Origin of plasmid DNA replication binding protein antibody; OriP binding protein antibody; OTTHUMP00000123406 antibody; SEMDJL2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Kinesin-like protein KIF22 protein (34-169AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells.
  • 基因功能參考文獻:
    1. Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules. PMID: 25743205
    2. we conclude that inhibition of KIF22 suppresses cancer cell proliferation by delaying mitotic exit through the transcriptional upregulation of CDC25C. PMID: 24626146
    3. Whole-exome sequencing identifies mutations of KIF22 in spondyloepimetaphyseal dysplasia with joint laxity, leptodactylic type PMID: 22152677
    4. Recurrent dominant mutations affecting two adjacent residues in the motor domain of the monomeric kinesin KIF22 result in skeletal dysplasia and joint laxity PMID: 22152678
    5. in all breast tumor tissues analyzed, variations in the Kid/KIF22 mRNA levels mirrored those seen with SIAH-1 mRNAs. PMID: 20144232
    6. These results are consistent with Kid having a role in chromosome congression in vivo, where it would be responsible for the polar ejection forces acting on the chromosome arms. PMID: 12606572
    7. its molecular structure and interaction with microtubules PMID: 12692123
    8. These results suggest that distinct from its role in chromosome movement, Kid contributes to spindle morphogenesis by mediating spindle microtubules stabilization. PMID: 16176979
    9. human Aurora B and Kid are identified as APC/C(Cdh1) substrates PMID: 17726374
    10. Association of importin-beta and -alpha with hKid triggers the initial targeting of hKid to mitotic chromosomes; local Ran-GTP-mediated cargo release promotes the accumulation of hKid on chromosomes. PMID: 18268099
    11. These data suggest that Kid-mediated anaphase/telophase chromosome compaction prevents formation of multinucleated cells. PMID: 18329364

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  • 相關疾病:
    Spondyloepimetaphyseal dysplasia with joint laxity, 2 (SEMDJL2)
  • 亞細胞定位:
    Nucleus. Cytoplasm, cytoskeleton.
  • 蛋白家族:
    TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
  • 組織特異性:
    Expressed in bone, cartilage, joint capsule, ligament, skin, and primary cultured chondrocytes.
  • 數據庫鏈接:

    HGNC: 6391

    OMIM: 603213

    KEGG: hsa:3835

    STRING: 9606.ENSP00000160827

    UniGene: Hs.612151



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