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  4. IPO9 Recombinant Monoclonal Antibody

IPO9 Recombinant Monoclonal Antibody

  • 中文名稱：
    IPO9 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA997477A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of Importin 9 expression in HepG2 cells using Importin 9 antibody. Green, isotype control; red, Importin 9.
    • Immunocytochemical staining of HepG2 cells with Importin 9 antibody. Nuclei were stained blue with DAPI; Importin 9 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using importin 9 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with importin 9 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    IPO9
  • 別名：
    IPO9; Importin 9; Imp9; Ran-Binding Protein 9; Importin-9; FLJ10402; RanBP9; IMP9; KIAA1192; RANBP9
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human IPO9 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    19E6
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of RPS7, RPL18A, RPL6, histone H2A, histone H2B and histone. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. Mediates the nuclear import of actin.
  • 基因功能參考文獻：
    1. CFL1 itself does not translocate actin into the cell nucleus but this transport requires the functional expression of IPO9. PMID: 26934847
    2. IPO9 associates with 2 stable stem-loop structures of the IFN-epsilon 5'UTR. IPO9 overexpression decreased, and IPO9 silencing increased basal IFN-epsilon expression. PMID: 23851686
    3. specific interaction between a member of the importin beta/karyopherin beta superfamily, importin 9, and the A subunit of PP2A (PR65) PMID: 12670497
  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Importin beta family
  • 數據庫鏈接：

    HGNC: 19425

    KEGG: hsa:55705

    STRING: 9606.ENSP00000354742

    UniGene: Hs.596014