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  4. EIF2A Recombinant Monoclonal Antibody

EIF2A Recombinant Monoclonal Antibody

  • 中文名稱：
    EIF2A Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA204842A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of Eukaryotic translation initiation factor 2A expression in HepG2 cells using Eukaryotic translation initiation factor 2A antibody. Green, isotype control; red, Eukaryotic translation initiation factor 2A.
    • Immunocytochemical staining of HT-1080 cells with Eukaryotic translation initiation factor 2A antibody. Nuclei were stained blue with DAPI; Eukaryotic translation initiation factor 2A was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
    • Western blotting analysis using Eukaryotic translation initiation factor 2A antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with Eukaryotic translation initiation factor 2A antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    65 kDa eukaryotic translation initiation factor 2; Eukaryotic translation initiation factor 2A; ACDA02; EIF 2A; CDA02; MSTP004; MSTP089; EIF2; eif2a; eIF-2A
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human EIF2A protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    19A3
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
  • 基因功能參考文獻：
    1. Data suggest that neither eIF2A nor eIF2D are involved in the translation of this Sindbis virus subgenomic mRNA (sgmRNA) bearing non-AUG codons. PMID: 28240315
    2. HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF-2a ubiquitylation and degradation. PMID: 29233968
    3. POSTN may function as a protective factor for osteoblasts during this process by inhibiting the eIF2alphaATF4 pathway. PMID: 29207036
    4. findings indicate that MSI1 plays a leading role in stress granule formation that grants cancer stem cell properties and chemoresistant stress granules in GBM, in response to stressful conditions via the PKR/eIF2alpha signalling cascade. PMID: 29486283
    5. There was no statistically significant difference in IFN therapeutic effectiveness among the patients with different genotypes of eIF-2a-reg2. PMID: 17407708
    6. activation by mechanical force PMID: 15781241
    7. FN has a role in controlling translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways PMID: 15961545

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  • 蛋白家族：
    WD repeat EIF2A family
  • 組織特異性：
    Widely expressed. Expressed at higher level in pancreas, heart, brain and placenta.
  • 數據庫鏈接：

    HGNC: 3254

    OMIM: 609234

    KEGG: hsa:83939

    STRING: 9606.ENSP00000417229

    UniGene: Hs.655782