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DSTN Recombinant Monoclonal Antibody

  • 中文名稱：
    DSTN Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA599595A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of DSTN expression in H9c2 cells using DSTN antibody. Green, isotype control; red, DSTN.
    • Immunocytochemical staining of H9C2 cells with DSTN antibody. Nuclei were stained blue with DAPI; DSTN was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using DSTN antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with DSTN antibody and HRP-conjugated goat rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    DSTN
  • 別名：
    DSTN; Destrin, Actin Depolymerizing Factor; ACTDP; ADF; Actin-Depolymerizing Factor; Destrin; BA462D18.2 (Destrin (Actin Depolymerizing Factor ADF) (ACTDP)); Epididymis Secretory Sperm Binding Protein; Destrin (Actin Depolymerizing Factor); Epididymis Luminal Protein 32; BA462D18.2; HEL32; DSN
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human DSTN protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    25A12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.
  • 基因功能參考文獻：
    1. analysis of human Cof1, Cof2, and ADF effects on actin filament severing and turnover PMID: 26996939
    2. Destrin is upregulated in nerve-invasive pancreatic cancer cells and its expression might be related to perineural invasiveness PMID: 22898637
    3. The ADF/cofilin1-dependent severing of actin filaments exposes and promotes the activation of SPCA1, which pumps Ca(2+) into the lumen of the TGN for the sorting of the class of secretory cargo that binds Ca(2+). PMID: 21571222
    4. Changes in the expression of cytoskeletal regulatory proteins such as LIMK and cofilin may play a role in weakening thoracic aortic medial tissue, as a precondition to thoracic aortic dissection. PMID: 20873970
    5. The results of this study suggested that temporally regulated ADF/cofilin activities function in postsynaptic modifications of receptor number and spine size during synaptic plasticity. PMID: 20835250
    6. differences in actin binding by human ADF and cofilin PMID: 11812157
    7. Important sequence differences between actin-depolymerizing factor/cofilin were correlated with unique structural determinants in the F-actin-binding site to account for differences in biochemical activities of the two proteins. PMID: 14627701
    8. downregulated following UV exposure in epidermis PMID: 15816841
    9. In the absence of any crystal structures of ADF or cofilin in complex with actin, these studies provide further information about the binding sites on F-actin for these important actin regulatory proteins. PMID: 17196218
    10. destrin is a significant regulator of various processes important for invasive phenotype of human colon cancer Isreco1 cells whereas cofilin-1 may be involved in only a subset of them PMID: 17583572

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  • 蛋白家族：
    Actin-binding proteins ADF family
  • 組織特異性：
    Widely distributed in various tissues.
  • 數據庫鏈接：

    HGNC: 15750

    OMIM: 609114

    KEGG: hsa:11034

    STRING: 9606.ENSP00000246069

    UniGene: Hs.304192