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CRTC3 Recombinant Monoclonal Antibody

  • 中文名稱:
    CRTC3 Recombinant Monoclonal Antibody
  • 貨號:
    CSB-RA103166A0HU
  • 規格:
    ¥1320
  • 圖片:
    • Flow cytometric analysis of CRTC3 expression in HeLa cells using CRTC3 antibody. Green, isotype control; red, CRTC3.
    • Immunocytochemical staining of Hela cells with CRTC3 antibody. Nuclei were stained blue with DAPI; CRTC3 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
    • Western blotting analysis using CRTC3 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with CRTC3 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CRTC3; CREB Regulated Transcription Coactivator 3; CREB-Regulated Transcription Coactivator 3; FLJ21868; TORC-3; TORC3; Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 3; Transducer Of Regulated CAMP Response Element-Binding Protein 3; Transducer Of Regulated CREB Protein 3; Transducer Of CREB Protein 3
  • 反應種屬:
    Human, Mouse, Rat
  • 免疫原:
    Recombinant Human CRTC3 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    Rabbit IgG
  • 純化方式:
    Affinity-chromatography
  • 克隆號:
    3B8
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, FC, ICC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
  • 基因功能參考文獻:
    1. CRTC3-MAML2 gene fusion occurs in hidradenomas. PMID: 29079171
    2. CRTC3 polymorphism was associated with the onset of acute coronary syndrome in Han Chinese patients, which may be related to the imbalance of the lipid metabolism PMID: 29979427
    3. findings suggest further characterization of MECs is needed before considering the CRTC1/3-MAML2 gene fusion as a prognostic biomarker PMID: 28438292
    4. revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions in cutaneous hidradenoma PMID: 27402217
    5. The CRTC3 polymorphism rs3862434 is associated with the plasma level of total cholesterol, and rs11635252 is associated with the risks of overweight and hypertriglyceridemia in a Chinese Han population. PMID: 24264430
    6. Metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands did not harbor CRTC1-MAML2 and CRTC3-MAML2 fusion transcripts, respectively, or MAML2 gene rearrangement. PMID: 24121173
    7. mucoepidermoid carcinoma of the salivary glands positive for CRTC1-MAML2 or CRTC3-MAML2 fusion formed a favourable tumour subset that was distinct from fusion-negative cases PMID: 21668476
    8. CRTC3 plays a selective role in mitochondrial biogenesis in response to rotenone PMID: 21536665
    9. As a common human CRTC3 variant with increased transcriptional activity is associated with adiposity in two distinct Mexican-American cohorts, results suggest that adipocyte CRTC3 may play a role in the development of obesity in humans PMID: 21164481
    10. Mucoepidermoid carcinomas possessing CRTC3-MAML2 fusion may be associated with favorable clinicopathological features and patients may be younger than those with CRTC1-MAML2 fusion or those with no detectable gene fusion. PMID: 19749740
    11. transducer of regulated cyclic AMP-response element-binding protein 3 (TORC3), a co-activator of CREB, is involved in Tax-induced transcriptional activation from the HTLV-I LTR PMID: 15466468
    12. These results strongly suggest that TORCs play a key role in linking these external signals to the transcriptional program of adaptive mitochondrial biogenesis by activating PGC-1alpha gene transcription. PMID: 16980408
    13. BCL3 functions as a repressor of HTLV-1 LTR-mediated transcription through interactions with TORC3 PMID: 17644518
    14. study reports for the first time a CRTC3-MAML2 fusion gene in a mucoepidermoid carcinoma, as determined by RT-PCR and sequencing. PMID: 18050304

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  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    TORC family
  • 組織特異性:
    Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.
  • 數據庫鏈接:

    HGNC: 26148

    OMIM: 608986

    KEGG: hsa:64784

    STRING: 9606.ENSP00000268184

    UniGene: Hs.567572



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