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  4. BAZ1B Recombinant Monoclonal Antibody

BAZ1B Recombinant Monoclonal Antibody

  • 中文名稱：
    BAZ1B Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA299479A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of BAZ1B expression in HeLa cells using BAZ1B antibody. Green, isotype control; red, BAZ1B.
    • Immunocytochemical staining of Hela cells with BAZ1B antibody. Nuclei were stained blue with DAPI; BAZ1B was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using BAZ1B antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with BAZ1B antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    BAZ1B; Bromodomain Adjacent To Zinc Finger Domain 1B; WSTF; WBSCR10; WBSCR9; Williams-Beuren Syndrome Chromosomal Region 10 Protein; Williams-Beuren Syndrome Chromosomal Region 9 Protein; Williams Syndrome; Transcription Factor; Tyrosine-Protein Kinase BAZ1B; Transcription Factor; WSTF; EC 2.7.10.2; HWALp2; Bromodomain Adjacent To Zinc Finger Domain Protein 1B; Williams-Beuren Syndrome Chromosome Region 10; Williams-Beuren Syndrome Chromosome Region 9; WBSC10
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human BAZ1B protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    3F6
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template. The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex. The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription. Within the B-WICH complex has a role in RNA polymerase III transcription. Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication.
  • 基因功能參考文獻：
    1. promotes recovery after DNA damage, in part by recruiting SMARCA5 to damaged chromatin PMID: 29021563
    2. Data show that Williams-Beuren syndrome transcription factor (WSTF) release was mediated by neuregulin-3 (NRG3) following KRASG12V expression in intestinal epithelial cells. PMID: 27449290
    3. WSTF may act as an oncoprotein in lung cancer to accelerate tumor aggressiveness. PMID: 27449264
    4. A pivotal role for BAZ1B in neurodevelopment was revealed and its haploinsufficiency was implicated as a likely contributor to the neurological phenotypes in Williams syndrome through transcriptional dysregulation. PMID: 26755828
    5. EB1089 inhibits aromatase expression by dissociation of comodulator WSTF from the CYP19A1 promoter. PMID: 23085504
    6. This review describes the three known WSTF-containing complexes and discuss their various roles as well as mechanisms of regulating WSTF activity. PMID: 21326359
    7. A multiprotein complex containing WSTF, nuclear myosin 1 (NM1), and SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily A member 5 protein(SNF2h) is required for ribosomal DNA transcription. PMID: 16514417
    8. WSTF phosphorylates Tyr 142 of H2A.X, and WSTF activity has an important role in regulating several events that are critical for the DNA damage response PMID: 19092802

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  • 相關疾病：
    BAZ1B is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of BAZ1B may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    WAL family, BAZ1B subfamily
  • 組織特異性：
    Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary.
  • 數據庫鏈接：

    HGNC: 961

    OMIM: 605681

    KEGG: hsa:9031

    STRING: 9606.ENSP00000342434

    UniGene: Hs.743372