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SPG21 Antibody, Biotin conjugated

  • 中文名稱:
    SPG21兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào):
    CSB-PA889158LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) SPG21 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    SPG21 antibody; ACP33 antibody; BM-019 antibody; GL010 antibody; Maspardin antibody; Acid cluster protein 33 antibody; Spastic paraplegia 21 autosomal recessive Mast syndrome protein antibody; Spastic paraplegia 21 protein antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Maspardin protein (1-308AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    May play a role as a negative regulatory factor in CD4-dependent T-cell activation.
  • 基因功能參考文獻(xiàn):
    1. HBV X gene enhanced SPG21 gene promoter activity, SPG21 mRNA expression and SPG21 protein production in HepG2 cells in a dose-dependent manner. PMID: 21205478
    2. frameshift results in the premature termination of the encoded product, which is designated "maspardin" (Mast syndrome, spastic paraplegia, autosomal recessive with dementia) PMID: 14564668
    3. Data report that maspardin localizes prominently to cytoplasm as well as to membranes, possibly at trans-Golgi network/late endosomal compartments, and that maspardin interacts with the aldehyde dehydrogenase ALDH16A1. PMID: 19184135
  • 相關(guān)疾病:
    Spastic paraplegia 21, autosomal recessive (SPG21)
  • 亞細(xì)胞定位:
    Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Partially localized in the cytosol but also accumulated on an intracellular vesicular compartment. Colocalizes with CD4 on endosomal/trans-Golgi network.
  • 蛋白家族:
    AB hydrolase superfamily
  • 組織特異性:
    Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in J.CaM1.6, HuT 78 and HeLa cell lines (at protein level).
  • 數(shù)據(jù)庫鏈接:

    HGNC: 20373

    OMIM: 248900

    KEGG: hsa:51324

    STRING: 9606.ENSP00000204566

    UniGene: Hs.242458



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