PRPF4 Antibody

說明書

產品詳情

Uniprot No.：

O43172
基因名：

PRPF4
別名：

hPrp4 antibody; HPRP4P antibody; PRP4 antibody; PRP4 homolog antibody; PRP4 pre mRNA processing factor 4 homolog (yeast) antibody; PRP4/STK/WD splicing factor antibody; PRP4_HUMAN antibody; Prp4p antibody; PRPF4 antibody; RP70 antibody; SNRNP60 antibody; U4/U6 small nuclear ribonucleoprotein Prp4 antibody; U4/U6 snRNP 60 kDa protein antibody; WD splicing factor Prp4 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human PRPF4
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).
基因功能參考文獻：
1. The p.R192H variant of PRPF4 represents a functional null allele which compromises the function of the tri-snRNP, reinforcing the notion that this spliceosomal particle is of crucial importance in the physiology of the retina. PMID: 25383878
2. PRPF4 missense mutations is associated with autosomal dominant retinitis pigmentosa. PMID: 24419317
3. the requirement of enzymatic activity of PRP4 in regulating cancer cell growth and identified an array of potential novel substrates through orthogonal proteomics approaches PMID: 24003220
4. interaction between Hprp3p and Hprp4p PMID: 11971898
5. PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores. PMID: 17998396
6. PRP-4 belongs to the serine/threonine protein kinase family, plays a role in pre-mRNA splicing and cell mitosis, and interacts with CLK1 PMID: 18687998
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相關疾病：

Retinitis pigmentosa 70 (RP70)
亞細胞定位：

Nucleus. Nucleus speckle.
數據庫鏈接：

HGNC: 17349

OMIM: 607795

KEGG: hsa:9128

STRING: 9606.ENSP00000363313

UniGene: Hs.744014

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