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PMVK Antibody

  • 中文名稱：
    PMVK兔多克隆抗體
  • 貨號：
    CSB-PA018258GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    PMVK
  • 別名：
    hPMK antibody; HUMPMKI antibody; OTTHUMP00000035546 antibody; Phosphomevalonate kinase antibody; PMK antibody; PMK PEN antibody; PMKA antibody; PMKase antibody; PMKI antibody; PMKPEN antibody; PMVK antibody; PMVK_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human PMVK
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites.
  • 基因功能參考文獻：
    1. Data indicate that exome sequencing revealed disseminated superficial porokeratosis (DSP)-associated mutations in phosphomevalonate kinase gene (PMVK). PMID: 27052676
    2. found an exclusive cytosolic localization of both endogenously expressed PMVK(in human fibroblasts, human liver, and HEK293 cells) and overexpressed PMVK. No indication of a peroxisomal localization was obtained. PMID: 14729858
    3. Functional evaluation of conserved basic residues in PMVK is reported. PMID: 17902708
    4. This is the first report of hPMK crystal structure that suggests a potential substrate binding site and a possible enzyme catalytic mechanism. PMID: 18618710
    5. Binding of mevalonate 5-phosphate causes the phosphomevalonate kinase structure to compress (tau(c) = 13.5 nsec), whereas subsequent binding of Mg-ADP opens the structure up (tau(c) = 15.6 nsec). PMID: 18798562

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  • 相關疾病：
    Porokeratosis 1, multiple types (POROK1)
  • 亞細胞定位：
    Cytoplasm, cytosol.
  • 組織特異性：
    Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta and lung.
  • 數據庫鏈接：

    HGNC: 9141

    OMIM: 175800

    KEGG: hsa:10654

    STRING: 9606.ENSP00000357452

    UniGene: Hs.30954