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PMVK Monoclonal Antibody

  • 中文名稱：
    PMVK Monoclonal Antibody
  • 貨號(hào)：
    CSB-MA785921
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western blotting analysis using phosphomevalonate kinase antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with phosphomevalonate kinase antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Mouse anti-Homo sapiens (Human) PMVK Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    PMVK
  • 別名：
    PMVK; Phosphomevalonate Kinase; HUMPMKI; PMKA; PMK; Testis Tissue Sperm-Binding Protein Li 95mP; EC 2.7.4.2; PMKASE; POROK1; PMKase; PMKI; HPMK
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human PMVK protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG2b
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    6D1
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites.
  • 基因功能參考文獻(xiàn)：
    1. Data indicate that exome sequencing revealed disseminated superficial porokeratosis (DSP)-associated mutations in phosphomevalonate kinase gene (PMVK). PMID: 27052676
    2. found an exclusive cytosolic localization of both endogenously expressed PMVK(in human fibroblasts, human liver, and HEK293 cells) and overexpressed PMVK. No indication of a peroxisomal localization was obtained. PMID: 14729858
    3. Functional evaluation of conserved basic residues in PMVK is reported. PMID: 17902708
    4. This is the first report of hPMK crystal structure that suggests a potential substrate binding site and a possible enzyme catalytic mechanism. PMID: 18618710
    5. Binding of mevalonate 5-phosphate causes the phosphomevalonate kinase structure to compress (tau(c) = 13.5 nsec), whereas subsequent binding of Mg-ADP opens the structure up (tau(c) = 15.6 nsec). PMID: 18798562

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  • 相關(guān)疾病：
    Porokeratosis 1, multiple types (POROK1)
  • 亞細(xì)胞定位：
    Cytoplasm, cytosol.
  • 組織特異性：
    Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta and lung.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 9141

    OMIM: 175800

    KEGG: hsa:10654

    STRING: 9606.ENSP00000357452

    UniGene: Hs.30954