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DARS Antibody

  • 中文名稱：
    DARS兔多克隆抗體
  • 貨號：
    CSB-PA006505LA01HU
  • 規格：
    ￥440
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) DARS Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DARS
  • 別名：
    Aspartate tRNA ligase 1 cytoplasmic antibody; Aspartate tRNA ligase antibody; Aspartate--tRNA ligase antibody; Aspartyl tRNA synthetase antibody; Aspartyl tRNA synthetase cytoplasmic antibody; Aspartyl-tRNA synthetase antibody; AspRS antibody; Cell proliferation inducing gene 40 protein antibody; Cell proliferation inducing protein 40 antibody; Cell proliferation-inducing gene 40 protein antibody; cytoplasmic antibody; Dars antibody; DKFZp781B11202 antibody; MGC111579 antibody; SYDC_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Aspartate--tRNA ligase, cytoplasmic protein (1-300AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，DARS Antibody (CSB-PA006505LA01HU)，的標記方式是Non-conjugated。對于DARS Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA006505LB01HU DARS Antibody, HRP conjugated ELISA
    FITC CSB-PA006505LC01HU DARS Antibody, FITC conjugated
    Biotin CSB-PA006505LD01HU DARS Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
  • 基因功能參考文獻：
    1. Genetic variants of the DARS gene may influence individual susceptibility to isolated VSD in Chinese Han population. Risk of VSD was significantly associated with rs2164331 [G/A; odds ratio (OR) = 0.78, 95% confidence interval (CI) = 0.69-0.91; P = 3.17 x 10(-3)], rs6738266 [G/A; OR = 1.17, 95% CI = 1.05-1.29, P = 1.83 x 10(-3)], and rs309143 [G/A; OR = 1.09, 95% CI = 1.01-1.17; P = 3.12 x 10(-2)]. PMID: 27871331
    2. Report on the crystal structure of human cytosolic aspartyl-tRNA synthetase (DRS) at a resolution of 2.25 A. PMID: 23609930
    3. Mutations in DARS cause hypomyelination with brain stem and spinal cord involvement and leg spasticity. PMID: 23643384
    4. the N-terminus shows a less-ordered structure with flexible beta-turn, suggesting that when tRNA is stretched, the dissociation rate of Asp-tRNA from aspartyl-tRNA synthetase is reduced, giving time for elongation factor 1alpha to interact with Asp-tRNA. PMID: 12824064
  • 相關疾病：
    Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL)
  • 亞細胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Class-II aminoacyl-tRNA synthetase family, Type 2 subfamily
  • 組織特異性：
    Expression in the developing and adult brain shows similar patterns. Highly expressed in the ventricular and subventricular zones, including hippocampal subfields, the midlateral temporal cortex and the frontal polar cortex. The cerebellum, cerebral corte
  • 數據庫鏈接：

    HGNC: 2678

    OMIM: 603084

    KEGG: hsa:1615

    STRING: 9606.ENSP00000264161

    UniGene: Hs.503787