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DARS Antibody

  • 中文名稱(chēng)：
    DARS兔多克隆抗體
  • 貨號(hào)：
    CSB-PA006505GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    DARS
  • 別名：
    Aspartate tRNA ligase 1 cytoplasmic antibody; Aspartate tRNA ligase antibody; Aspartate--tRNA ligase antibody; Aspartyl tRNA synthetase antibody; Aspartyl tRNA synthetase cytoplasmic antibody; Aspartyl-tRNA synthetase antibody; AspRS antibody; Cell proliferation inducing gene 40 protein antibody; Cell proliferation inducing protein 40 antibody; Cell proliferation-inducing gene 40 protein antibody; cytoplasmic antibody; Dars antibody; DKFZp781B11202 antibody; MGC111579 antibody; SYDC_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human DARS
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
  • 基因功能參考文獻(xiàn)：
    1. Genetic variants of the DARS gene may influence individual susceptibility to isolated VSD in Chinese Han population. Risk of VSD was significantly associated with rs2164331 [G/A; odds ratio (OR) = 0.78, 95% confidence interval (CI) = 0.69-0.91; P = 3.17 x 10(-3)], rs6738266 [G/A; OR = 1.17, 95% CI = 1.05-1.29, P = 1.83 x 10(-3)], and rs309143 [G/A; OR = 1.09, 95% CI = 1.01-1.17; P = 3.12 x 10(-2)]. PMID: 27871331
    2. Report on the crystal structure of human cytosolic aspartyl-tRNA synthetase (DRS) at a resolution of 2.25 A. PMID: 23609930
    3. Mutations in DARS cause hypomyelination with brain stem and spinal cord involvement and leg spasticity. PMID: 23643384
    4. the N-terminus shows a less-ordered structure with flexible beta-turn, suggesting that when tRNA is stretched, the dissociation rate of Asp-tRNA from aspartyl-tRNA synthetase is reduced, giving time for elongation factor 1alpha to interact with Asp-tRNA. PMID: 12824064
  • 相關(guān)疾病：
    Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL)
  • 亞細(xì)胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Class-II aminoacyl-tRNA synthetase family, Type 2 subfamily
  • 組織特異性：
    Expression in the developing and adult brain shows similar patterns. Highly expressed in the ventricular and subventricular zones, including hippocampal subfields, the midlateral temporal cortex and the frontal polar cortex. The cerebellum, cerebral corte
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 2678

    OMIM: 603084

    KEGG: hsa:1615

    STRING: 9606.ENSP00000264161

    UniGene: Hs.503787