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中文名稱：
CTNNB1兔多克隆抗體
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貨號：
CSB-PA284161
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規(guī)格：
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圖片：
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：
Rabbit anti-Homo sapiens (Human) CTNNB1 Polyclonal antibody
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Uniprot No.：
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基因名：
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宿主：
Rabbit
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反應(yīng)種屬：
Human,Mouse,Rat
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免疫原：
Synthetic peptide corresponding to a region derived from 757-770 amino acids of Human Catenin beta-1
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免疫原種屬：
Homo sapiens (Human)
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克隆類型：
Polyclonal
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濃度：
It differs from different batches. Please contact us to confirm it.
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產(chǎn)品提供形式：
Liquid
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應(yīng)用范圍：
ELISA,WB
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推薦稀釋比：
| Application |
Recommended Dilution |
| WB |
1:500-1:2000 |
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Protocols：
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儲存條件：
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
靶點(diǎn)詳情
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功能：
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling.
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相關(guān)疾病：
Colorectal cancer (CRC); Pilomatrixoma (PTR); Medulloblastoma (MDB); Ovarian cancer (OC); Mesothelioma, malignant (MESOM); Mental retardation, autosomal dominant 19 (MRD19); Vitreoretinopathy, exudative 7 (EVR7)
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亞細(xì)胞定位：
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cell junction, synapse. Cytoplasm, cytoskeleton, cilium basal body.
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蛋白家族：
Beta-catenin family
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組織特異性：
Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level). Expressed in breast cancer tissues (at protein level).
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數(shù)據(jù)庫鏈接：
Most popular with customers
Gel: 10%SDS-PAGELane1: Mouse brain tissue lysateLane2: Mouse lung tissue lysateLysates: 24 ug per lanePrimary antibody: 1/350 dilutionSecondary antibody: Donkey anti Rabbit IgG - H&L (HRP) at 1/5000 dilutionExposure time: 1 minute
