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MPI Monoclonal Antibody

  • 中文名稱：
    MPI Monoclonal Antibody
  • 貨號：
    CSB-MA273467
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of Mannose phosphate isomerase expression in HeLa cells using Mannose phosphate isomerase antibody. Green, isotype control; red, Mannose phosphate isomerase.
    • Western blotting analysis using mannose phosphate isomerase antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with mannose phosphate isomerase antibody and HRP-conjugated goat mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) MPI Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    MPI
  • 別名：
    MPI; Mannose Phosphate Isomerase; Mannose-6-Phosphate Isomerase; Phosphohexomutase; EC 5.3.1.8; PMI1; PMI; Phosphomannose Isomerase 1; Phosphomannose Isomerase; EC 5.3.1; CDG1B
  • 宿主：
    Mouse
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human MPI protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    6D9
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
  • 基因功能參考文獻：
    1. This work provides mechanistic evidence by which mannose phosphate isomerase loss induces p53, and identifies mannose phosphate isomerase as a novel regulator of p53 and Warburg metabolism. PMID: 28644127
    2. Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts PMID: 21949237
    3. The mannose-6-phosphate-enzyme complex is developed and the key residues involved in the ligand binding are determined. Our results suggest a hydride transfer mechanism of alpha-hydrogen between the C1 and C2 positions. PMID: 16488169
  • 相關疾病：
    Congenital disorder of glycosylation 1B (CDG1B)
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Mannose-6-phosphate isomerase type 1 family
  • 組織特異性：
    Expressed in all tissues, but more abundant in heart, brain and skeletal muscle.
  • 數據庫鏈接：

    HGNC: 7216

    OMIM: 154550

    KEGG: hsa:4351

    STRING: 9606.ENSP00000318318

    UniGene: Hs.75694