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  4. ANXA11 Monoclonal Antibody

ANXA11 Monoclonal Antibody

  • 中文名稱：
    ANXA11 Monoclonal Antibody
  • 貨號：
    CSB-MA557994
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of Annexin A11 expression in HepG2 cells using Annexin A11 antibody. Green, isotype control; red, Annexin A11.
    • Immunocytochemical staining of HepG2 cells with Annexin A11 antibody. Nuclei were stained blue with DAPI; Annexin A11 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and Smart Gain: Low. Scale bar, 20 μm.
    • Western blotting analysis using annexin A11 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with annexin A11 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) ANXA11 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    ANXA11
  • 別名：
    ANXA11; Annexin A11; Annexin XI; ANX11; Calcyclin-Associated Annexin 50; 56 KDa Autoantigen; Annexin-11; CAP-50; Epididymis Secretory Sperm Binding Protein; IBMWMA; ALS23; CAP50
  • 宿主：
    Mouse
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human ANXA11 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    4H12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:100-1:500
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Binds specifically to calcyclin in a calcium-dependent manner. Required for midbody formation and completion of the terminal phase of cytokinesis.
  • 基因功能參考文獻：
    1. Both ANXA11 G38R protein and ANXA11 D40G protein showed a shorter half-life than ANXA11 wild type protein, while there was no difference between ANXA11 G38R protein and ANXA11 D40G protein. There was no visible insoluble substance in the NP-40 lysates for ANXA11 wild type protein, ANXA11 G38R protein and ANXA11 D40G protein. G38R and D40G mutations reduce the stability of ANXA11 protein. PMID: 30109997
    2. Genetic variants in RAB23 and ANXA11 genes were associated with an increased risk of sarcoidosis-associated uveitis. PMID: 29416296
    3. ANXA11 plays a critical role in regulating gastric cancer proliferation, migration, and invasion. PMID: 29306955
    4. Data conclude that mutations in ANXA11 are associated with ALS and implicate defective intracellular protein trafficking in disease pathogenesis. PMID: 28469040
    5. Letter: ANXA11 SNPs increase susceptibility to fibrosing sarcoiodosis in African Americans. PMID: 28079857
    6. Review/Meta-analysis: ANXA11 SNP rs2573346 and rs2789679 conferred protection against sarcoidosis. SNP rs1049550 may be a risk factor for sarcoidosis in overall population. PMID: 27537711
    7. ANXA11 rs1049550 and PPP1R15A rs557806 may improve the identification of mCRC patients sensitive to bevacizumab regimens, and further validation is required in large cohorts PMID: 27177629
    8. These findings point to a role for the polymorphisms of ANXA11 in sarcoidosis in a Chinese Han population, and may be informative for future genetic studies on sarcoidosis. PMID: 25056970
    9. findings suggest that AnxA11 maintains architectural and functional features of the ERES by coordinating with ALG-2 to stabilize Sec31A at the ERES. PMID: 25540196
    10. the associations of Anxa11 with Ca(2+)-regulated exocytosis, cytokinesis, sex differentiation, autoimmune diseases, thrombolysis and cancers are summarized--{REVIEW} PMID: 24508622
    11. Annexin A11 rs1049550*T allele exerts a significant protective effect on sarcoidosis susceptibility. PMID: 24032725
    12. LIFR rs3729740 and possibly ANXA11 rs1049550 may be useful as biomarkers for predicting whether metastatic colorectal cancer patients are sensitive to relevant target regimens, although further validation in large cohorts is needed. PMID: 23579219
    13. ANXA11 SNPs are associated with sarcoidosis in African Americans. PMID: 23151485
    14. ANXA11 rs1049550 single nucleotide polymorphism is the susceptibility marker in sarcoidosis, at least in Caucasians. PMID: 21562576
    15. Data confirm the strong association between variations in ANXA11 and sarcoidosis and support the hypothesis that ANXA11 represents a strong genetic risk factor for sarcoidosis. PMID: 20805159
    16. analysis of the sarcoidosis-associated variant of annexin A11 PMID: 20093723
    17. Pro/Gly/Tyr/Ala-rich hydrophobic region in AnxN masked the Ca(2+)-dependently exposed hydrophobic surface of ALG-2. PMID: 11883939
    18. The penta-EF-hand domain of ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca2+-dependent manner. PMID: 12445460
    19. calcium- and cell cycle-dependent association with the nuclear envelope PMID: 12601007
    20. annexin XI associates with the mitotic spindles and might play a role in cell division PMID: 12805373
    21. Annexin 11-depleted cells failed to complete cytokinesis and died by apoptosis, demonstrating an essential role for annexin 11. PMID: 15197175
    22. The strongest association signal maps to the ANXA11 (annexin A11) gene on chromosome 10q22.3. PMID: 19165924
    23. Immunohistochemistry analyses indicated that annexin A11 immunointensity inversely correlated with HMOX1 immunoreactivity in 142 ovarian cancer patients. PMID: 19484149

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  • 亞細胞定位：
    Cytoplasm. Melanosome. Nucleus envelope. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族：
    Annexin family
  • 數據庫鏈接：

    HGNC: 535

    OMIM: 602572

    KEGG: hsa:311

    STRING: 9606.ENSP00000265447

    UniGene: Hs.530291