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  4. Mouse Macrophage Inflammatory Protein 1β,MIP-1β ELISA kit

Mouse Macrophage Inflammatory Protein 1β,MIP-1β ELISA kit

  • 中文名稱：
    小鼠巨噬細(xì)胞炎性蛋白1β(MIP-1β/CCL4)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E04665m
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3200/￥2500
  • 促銷：
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠巨噬細(xì)胞炎性蛋白1β(MIP-1β/CCL4)酶聯(lián)免疫試劑盒（CSB-E04665m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CCL4含量。CCL4，即C-C趨化因子配體4，是一種由免疫細(xì)胞和腫瘤細(xì)胞分泌的細(xì)胞因子，主要在正常組織中不表達(dá)或弱表達(dá)，但在多種惡性腫瘤組織中異常高表達(dá)。CCL4與CCR5受體結(jié)合后，可招募免疫細(xì)胞，破壞腫瘤微環(huán)境穩(wěn)定性，參與致癌并促進(jìn)腫瘤發(fā)展。其研究機(jī)制涉及調(diào)節(jié)腫瘤微環(huán)境中的免疫細(xì)胞組成和功能，對腫瘤的發(fā)生發(fā)展及免疫逃逸有重要影響。試劑盒檢測范圍為12.5 pg/mL-800 pg/mL，本試劑盒采用特異性抗體對目標(biāo)蛋白進(jìn)行捕獲與檢測，操作流程標(biāo)準(zhǔn)化，適用于科研領(lǐng)域中對小鼠模型炎癥相關(guān)機(jī)制的研究，例如在感染性疾病模型、自身免疫疾病模型或免疫調(diào)節(jié)實(shí)驗(yàn)中定量分析MIP - 1β/CCL4的表達(dá)動態(tài)，亦可應(yīng)用于藥物開發(fā)或免疫干預(yù)研究中評估該趨化因子的水平變化。實(shí)驗(yàn)支持多種生物樣本類型檢測，為探索炎癥微環(huán)境及免疫調(diào)控網(wǎng)絡(luò)提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Ccl4 ELISA Kit; Mip1b ELISA Kit; Scya4 ELISA Kit; C-C motif chemokine 4 ELISA Kit; Immune activation protein 2 ELISA Kit; ACT-2 ELISA Kit; ACT2 ELISA Kit; Macrophage inflammatory protein 1-beta ELISA Kit; MIP-1-beta ELISA Kit; Protein H400 ELISA Kit; SIS-gamma ELISA Kit; Small-inducible cytokine A4 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    12.5 pg/mL-800 pg/mL
  • 靈敏度：
    3.12 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：

  • 線性度：

  • 回收率：

  • 標(biāo)準(zhǔn)曲線：

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Monokine with inflammatory and chemokinetic properties.
  • 基因功能參考文獻(xiàn)：
    1. CCL4-CCR5 axis can contribute to breast cancer metastasis to bone by mediating the interaction between cancer cells and fibroblasts in bone cavity. PMID: 27177471
    2. YY1 regulates lung CCL4 transcription in pulmonary tuberculosis. PMID: 26786659
    3. Ccl4 mRNAs increased within 5 h after injury in mouse cortical slices. PMID: 25895671
    4. CCL4 and CCL5 expression was higher in livers of infected WSX-1(-/-) mice than infected WT mice, and hepatic CD4 T cells from WSX-1(-/-) mice expressed higher levels of CCR5 than cells from WT mice PMID: 24244314
    5. CCL4 upregulation was associated with increased Snail expression and downregulation of p53/PTEN in high-grade PIN and prostate cancer PMID: 23878190
    6. These results suggest that MIP-1beta is a novel key mediator, and the peripheral MIP-1beta-CCR5 axis contributes to neuropathic pain. PMID: 22528550
    7. results indicate that MIP-1beta is involved in the recruitment of bone marrow-derived monocyte lineage cells PMID: 21912378
    8. increased responsiveness of murine eosinophils to MIP-1beta is mediated by CCR5 receptor in mice PMID: 12050188
    9. macrophage inflammatory protein-1beta is a hypoxia-induced neutrophil survival factor. PMID: 15630139
    10. MIP-1beta is overexpressed, and VE-cadherin is underexpressed in heart transplant allografts compared with isografts PMID: 15897346
    11. Overproduction of MIP-1beta in chemokine (C-C motif) receptor 5-deficient mice after collagen II-immunization may contribute partially to the occurrence of arthritis PMID: 15967376
    12. The expression and role CXCL12 and CCL4 and their receptors (CXCR4 and CCR5) in regulating thymocyte migration in conjunction with extracellular matrix during acute T. cruzi infection are investigated. PMID: 16637021
    13. ATF3 appears to be part of a control mechanism that limits the amount of CCL4 released by macrophages, preventing excessive inflammation. PMID: 16982098
    14. Antibody neutralization of CCL4 abrogates the ability of T-cells from IL-4-treated NOD mice to transfer protection against type 1 diabetes. PMID: 17327452

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 數(shù)據(jù)庫鏈接：


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