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Monkey Tumor necrosis factor α,TNF-α ELISA KIT

  • 中文名稱:
    猴腫瘤壞死因子α(TNF-α)酶聯(lián)免疫試劑盒
  • 貨號(hào):
    CSB-E10039Mo
  • 規(guī)格:
    96T/48T
  • 價(jià)格:
    ¥4200/¥3000
  • 促銷:
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    猴腫瘤壞死因子α(TNF-α)酶聯(lián)免疫試劑盒(CSB-E10039Mo)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的TNF含量。TNF即腫瘤壞死因子,是一種多功能細(xì)胞因子。在背景上,它最初因能使腫瘤組織出血壞死而被發(fā)現(xiàn)。其研究機(jī)制主要涉及參與免疫調(diào)節(jié)、炎癥反應(yīng)等過程。異常的TNF表達(dá)與多種疾病相關(guān),如類風(fēng)濕關(guān)節(jié)炎等,是相關(guān)疾病治療的重要靶點(diǎn)。試劑盒檢測范圍為1.56 pg/mL-100 pg/mL,該靶標(biāo)常用于靈長類動(dòng)物感染性疾病、自身免疫模型及炎癥機(jī)制研究;適用于恒河猴、食蟹猴等非人靈長類動(dòng)物的基礎(chǔ)研究,如病毒感染模型中細(xì)胞因子風(fēng)暴評估、免疫抑制劑作用機(jī)制探索,或通過組織樣本分析特定器官炎癥微環(huán)境變化,為神經(jīng)退行性疾病、代謝綜合征等科研方向提供關(guān)鍵數(shù)據(jù)支持;適用于實(shí)驗(yàn)室常規(guī)蛋白定量分析本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名:
    TNF; TNFA; TNFSF2; Tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Monkey
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    4.69 pg/mL-300 pg/mL
  • 靈敏度:
    2.345 pg/mL
  • 反應(yīng)時(shí)間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領(lǐng)域:
    Immunology
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:

  • 標(biāo)準(zhǔn)曲線:

  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評價(jià)

平均分:
5.0分 - 1 個(gè)評價(jià)

樣品類型:細(xì)胞培養(yǎng)上清液

樣品信息:其他 猴

稀釋比:其他 1:3,1;5,1:10

產(chǎn)品評價(jià): 我用CSB-E10039Mo檢測食蟹猴細(xì)胞培養(yǎng)上清液,標(biāo)曲OD值范圍為3.1274-0.2045,樣品檢測OD值范圍為1.112-0.109,檢測良好,標(biāo)曲正常。

By 榮老師

靶點(diǎn)詳情

  • 功能:
    Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.; The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
  • 基因功能參考文獻(xiàn):
    1. These interactions result in the induction of the TNF signaling pathway, activation of apoptosis, and DNA-damage stress response. PMID: 24743303
    2. Findings showed that both mucosal compartments harbor similar percentages of memory CD4(+) T cells and displayed comparable cytokine TNF-alpha responses to mitogenic stimulations prior to infection. PMID: 24610016
    3. Primary role for IL-1beta and TNF-alpha in the triggering of preterm labor associated with inflammation or infection. PMID: 17132473
  • 亞細(xì)胞定位:
    Cell membrane; Single-pass type II membrane protein.; [Tumor necrosis factor, membrane form]: Membrane; Single-pass type II membrane protein.; [Tumor necrosis factor, soluble form]: Secreted.; [C-domain 1]: Secreted.; [C-domain 2]: Secreted.
  • 蛋白家族:
    Tumor necrosis factor family
  • 數(shù)據(jù)庫鏈接:


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