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pfo

Perfringolysin O (PFO)是由肉毒梭菌(Clostridium perfringens)產生的毒素。其結構是一個大的單亞單位蛋白,具有約497個氨基酸,含有多個β-折疊和α螺旋結構。PFO主要通過與細胞膜中的膽固醇結合,形成聚合物,并形成可通透的孔道,導致細胞膜的破壞和溶解。這種溶孔作用會破壞細胞的完整性,導致溶解和細胞死亡。PFO主要通過膽固醇結合并引發細胞膜的溶解,導致細胞內外離子平衡失調,從而影響細胞的生存和功能。PFO和其變體可以用作生物學研究中的細胞膜溶解工具,用于探究細胞膜通透性和細胞膜受損的影響。在肉毒梭菌感染的情況下,PFO被認為是該菌致病性的重要因素之一,它參與了細胞的溶解和組織損傷,因此在了解和研究感染機制、藥物開發等方面有一定的應用價值。

熱銷產品

Recombinant Clostridium perfringens Perfringolysin O (pfo)

驗證數據

SDS-PAGE
CSB-EP314820CMB-SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LC-MS
CSB-EP314820CMB LC-MS-1

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS Analysis result of CSB-EP314820CMB could indicate that this peptide derived from E.coli-expressed Clostridium perfringens (strain 13 / Type A) pfo.

LC-MS
CSB-EP314820CMB LC-MS-2

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS Analysis result of CSB-EP314820CMB could indicate that this peptide derived from E.coli-expressed Clostridium perfringens (strain 13 / Type A) pfo.


pfo Antibodies

pfo for Clostridium perfringens

pfo Proteins

pfo Proteins for Clostridium perfringens

pfo Proteins for Clostridium perfringens (strain 13 / Type A)