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cGAS

cGAS,全稱環磷酸鳥苷-腺苷酸合成酶,是細胞內的一種重要蛋白,主要作用是感知細胞質中的異常雙鏈DNA,從而激活免疫反應。cGAS能夠識別多種細胞來源的核DNA和線粒體DNA,這一特性使其在抵抗多種含DNA的病原微生物感染中發揮關鍵作用。此外,cGAS還能感知腫瘤來源的DNA,產生抗腫瘤免疫應答。然而,當細胞核和線粒體中的DNA泄漏到細胞質中時,cGAS的異常激活也可能導致自身免疫性疾病的發生。目前,針對cGAS的藥物研發已成為治療自身免疫性疾病的重要方向,包括cGAS抑制劑和cGAS降解劑等,這些藥物有望為自身免疫性疾病的治療提供新的選擇。

熱銷產品

Recombinant Human Cyclic GMP-AMP synthase (CGAS), partial (CSB-EP822726HU)

驗證數據

CSB-EP822726HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP822726HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP822726HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MB21D1.

CSB-EP822726HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP822726HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MB21D1.

cGAS Proteins

cGAS Proteins for Homo sapiens (Human)