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VTCN1

VTCN1,即V結(jié)構(gòu)域含T細(xì)胞激活抑制因子1,是一種屬于B7家族的膜結(jié)合蛋白。它在多種細(xì)胞類型中表達(dá),包括腫瘤細(xì)胞和免疫細(xì)胞。VTCN1的作用機制涉及調(diào)節(jié)T細(xì)胞的激活和增殖,可能通過與B7家族其他成員相互作用影響T細(xì)胞受體(TCR)介導(dǎo)的信號通路。此外,VTCN1在腫瘤微環(huán)境中可能促進(jìn)腫瘤細(xì)胞的侵襲和轉(zhuǎn)移,以及腫瘤血管生成。VTCN1的表達(dá)在多種腫瘤中異常升高,并與患者的不良預(yù)后顯著相關(guān)。它在腫瘤免疫逃逸、轉(zhuǎn)移中可能發(fā)揮重要作用,因此被認(rèn)為是腫瘤治療的潛在靶點。同時,VTCN1的表達(dá)水平也被用作檢測腫瘤患者病情和治療效果的生物標(biāo)志物,具有重要的臨床應(yīng)用前景。

熱銷產(chǎn)品

VTCN1 Antibody (CSB-PA13005A0Rb)

驗證數(shù)據(jù)

CSB-PA13005A0Rb

Immunofluorescence staining of Hela cells with CSB-PA13005A0Rb at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-PA13005A0Rb

IHC image of CSB-PA13005A0Rb diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

VTCN1 Antibodies

VTCN1 for Homo sapiens (Human)

VTCN1 Proteins

VTCN1 Proteins for Homo sapiens (Human)

VTCN1 Proteins for Rattus norvegicus (Rat)

VTCN1 Proteins for Mus musculus (Mouse)

VTCN1 ELISA Kit

VTCN1 ELISA Kit for Homo sapiens (Human)



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