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VPS18

VPS18,別名PEP3,在多種組織中廣泛表達(dá),尤其在骨髓、腎臟等組織中表達(dá)量較高。VPS18的作用機(jī)制涉及其作為CORVET和HOPS復(fù)合體的核心亞基,這兩個(gè)復(fù)合體參與介導(dǎo)內(nèi)膜運(yùn)輸過程,特別是與晚期內(nèi)體/溶酶體相關(guān),可能介導(dǎo)內(nèi)體/溶酶體途徑中的囊泡運(yùn)輸步驟。VPS18對于維持細(xì)胞內(nèi)蛋白質(zhì)的正確分選和運(yùn)輸至關(guān)重要,其功能異常可能與某些遺傳性疾病相關(guān),如Hermansky-Pudlak綜合征。VPS18還參與調(diào)控神經(jīng)細(xì)胞存活、遷移和樹突發(fā)育等重要生理功能,對于研究人類神經(jīng)退行性疾病的診斷和防治新策略提供了新的理論依據(jù)和思路。

熱銷產(chǎn)品

VPS18 Antibody (CSB-PA882173LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA882173LA01HU

IHC image of CSB-PA882173LA01HU diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

VPS18 Antibodies

VPS18 for Homo sapiens (Human)

VPS18 Proteins

VPS18 Proteins for Homo sapiens (Human)